(R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid

Basic Information

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CAS Number

884512-77-0

Molecular Formula

C10H17NO5

Molecular Weight

231.25 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

Physical State

White to Yellow Solid

Boiling Point

369.5°C at 760 mmHg

Density

1.230

SMILES

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CC(C)(C)OC(=O)N1CCOC(C1)C(=O)O

InChI

InChI=1S/C10H17NO5/c1-10(2,3)16-9(14)11-4-5-15-7(6-11)8(12)13/h7H,4-6H2,1-3H3,(H,12,13)/t7-/m1/s1

InChIKey

LGWMTRPJZFEWCX-SSDOTTSWSA-N

LogP

0.7069000000000001

Topological Polar Surface Area

76.07 Å²

Hydrogen Bond Donor/Acceptor

1 / 6

Complexity

283

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid
(2R)-2,4-Morpholinedicarboxylic acid 4-(1,1-dimethylethyl) ester
(2R)-4-(1,1-Dimethylethyl) Ester 2,4-Morpholinedicarboxylic Acid
(R)-N-BOC-2-MORPHOLINECARBOXYLIC ACID
(R)-N-Boc-morpholine-2-carboxylic acid
(-)-(2R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid
(2R)-4-(tert-butoxycarbonyl)morpholin-2-carboxylic acid
(R)-4-BOC-MORPHOLINE-2-CARBOXYLIC ACID
(R)-4-tert-butoxycarbonylmorpholine-2-carboxylic acid
(R)-Morpholine-2,4-dicarboxylic acid 4-tert-butyl ester
4-{[(1,1-dimethylethyl)oxy]carbonyl}-2-morpholinecarboxylic acid
(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylicacid
(2R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid
(2R)-4-[(tert-butoxy)carbonyl]morpholine-2-carboxylic acid
(R)-N-Boc-2-morpholinecarboxylicacid
L
4-(1,1-Dimethylethyl) (2R)-2,4-morpholinedicarboxylate (ACI)
(2R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid
(2R)-4-[(2-Methylpropan-2-yl)oxycarbonyl]morpholine-2-carboxylic acid
(R)-2-Carboxymorpholine-4-carboxylic acid tert-butyl ester
(R)-N-Boc-2-morpholinecarboxylic acid
(R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid
(2R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic Acid; (R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic Acid; (R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic Acid
AC-25492
Z1263738221
SCHEMBL194709
(2R)-2,4-Morpholinedicarboxylic Acid-4-(1,1-Dimethylethyl)ester
(R)-N-Boc-Morpholine-2-carboxylic acid
(R)-4-tert-butyloxycarbonyl-2-morpholinecarboxylic acid
AKOS015901309
(2r)-(tert-butoxycarbonyl)morpholin-2-carboxylic acid

MDL Number

MFCD09260604

Customs Code

2934999090

FAQ

What are the physical and chemical properties of (R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid (CAS: 884512-77-0)?

(R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid is a colorless crystalline solid with a molecular weight of approximately 256.34 g/mol. It has a high solubility in organic solvents like DMSO and ethanol, and low solubility in water. This compound is known for its reactivity in esterification and amide formation. It exhibits good stability in air but is susceptible to hydrolysis in basic conditions.

How is (R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid (CAS: 884512-77-0) typically synthesized?

(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid can be synthesized through a multi-step process involving the protection of morpholine with tert-butoxy carbonyl (BOC) group. The synthesis involves the reaction of morpholine with BOC chloride in the presence of a base, followed by purification and derivatization steps. This method allows for a selective and high-yield synthesis of the compound.

What industries use (R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid (CAS: 884512-77-0)?

(R)-4-(tert-Butoxycarbonyl)morpholine-2-carboxylic acid is primarily used in the pharmaceutical and chemical industries. It serves as a key intermediate in the synthesis of various drugs and biologically active compounds. Additionally, it finds applications in the polymer industry for the development of new materials and in the electronics sector for the production of sensors and semiconductors.

What precautions should be taken when handling (R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid (CAS: 884512-77-0)?

When handling (R)-4-(tert-butoxycarbonyl)morpholine-2-carboxylic acid, it is essential to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a lab coat. This compound should be stored in a cool, dry place away from direct sunlight. In case of a spill, it is recommended to use a fume hood, and the spill should be cleaned up immediately using appropriate absorbent materials. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information and handling guidelines.