6-Fluoroquinazoline-2,4-diol

Basic Information

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CAS Number

88145-90-8

Molecular Formula

C8H5FN2O2

Molecular Weight

180.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

SMILES

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C1=CC2=C(C=C1F)C(=O)NC(=O)N2

InChI

InChI=1S/C8H5FN2O2/c9-4-1-2-6-5(3-4)7(12)11-8(13)10-6/h1-3H,(H2,10,11,12,13)

InChIKey

QUQJMNPJMVUMNE-UHFFFAOYSA-N

LogP

0.3554999999999999

Topological Polar Surface Area

65.72 Å²

Hydrogen Bond Donor/Acceptor

2 / 4

Complexity

257

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

6-Fluoroquinazoline-2,4-diol
2,4-Dihydroxyl-6-fluoroquinazoline
6-Fluoro-1,2,3,4-tetrahydroquinazoline-2,4-dione
6-fluoro-1H-quinazoline-2,4-dione
6-fluoro-2,4(1H,3H)-Quinazolinedione
2,4-Dihydroxy-6-fluoroquinazoline
6-fluoro-2,4-dioxo-1,2,3,4-tetrahydroquinazoline
6-fluoroquinazolin-2,4(1H,3H)-1,3-dione
6-fluoroquinazoline-2,4(1H,3H)-dione
2,4(1H,3H)-Quinazolinedione, 6-fluoro-
PubChem14296
QUQJMNPJMVUMNE-UHFFFAOYSA-N
2?4-dihydroxyl-6-fluoroquinazoline
6-fluoroquinazoline-2,4-diol
6-Fluoro-2,4(1H,3H)-quinazolinedione (ACI)
6-Fluoroquinazoline-2,4(1H,3H)-dione
CS-D0544
J-518759
2AfAE'A centa' notA inverted exclamation markAfasA'A poundAfAE'A centa' notA inverted exclamation markAfasA'A not4-dihydroxyl-6-fluoroquinazoline
AKOS015856544
6-FLUORO-1,3-DIHYDROQUINAZOLINE-2,4-DIONE
DTXSID10586542
6-fluoro-1,2,3,4-tetrahydroquinazoline-2,4-dione
6-Fluoroquinazoline-2 pound not4-diol
88145-90-8
DB-077198
EN300-1666755
GS-0614
2 pound not4-dihydroxyl-6-fluoroquinazoline
24-dihydroxyl-6-fluoroquinazoline
Z1503739886

MDL Number

MFCD12024573

Customs Code

2933990090

FAQ

What are the physical and chemical properties of 6-Fluoroquinazoline-2,4-diol (CAS: 88145-90-8)?

6-Fluoroquinazoline-2,4-diol is a solid with a melting point of 214-216°C. It has a molecular weight of 230.07 g/mol and is slightly soluble in water. It is reactive towards nucleophiles and can undergo various chemical transformations. The compound is stable under normal conditions but should be stored in a cool, dry place away from heat sources and oxidizing agents.

How is 6-Fluoroquinazoline-2,4-diol (CAS: 88145-90-8) typically synthesized?

6-Fluoroquinazoline-2,4-diol is typically synthesized via a multi-step reaction involving the conversion of a starting amine to an amide, followed by the introduction of a fluoro group, and finally the reduction of an intermediate aldehyde to obtain the diol. Catalysts like palladium are often used to enhance the selectivity and yield of the reactions.

What industries use 6-Fluoroquinazoline-2,4-diol (CAS: 88145-90-8)?

6-Fluoroquinazoline-2,4-diol is primarily used in the pharmaceutical industry for the development of drug candidates. It may also find applications in the polymer industry for creating functional materials, and in the sensor industry for developing chemical sensors due to its unique chemical properties.

What precautions should be taken when handling 6-Fluoroquinazoline-2,4-diol (CAS: 88145-90-8)?

Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn when handling 6-Fluoroquinazoline-2,4-diol. It should be stored in a cool, dry place, away from heat and oxidizing agents. Fume hoods should be used during handling to minimize inhalation risk. In case of a spill, neutralize the spill with an appropriate chemical and clean up with care, following the Safety Data Sheet (SDS) guidelines for this compound.