5-Bromo-2-chloro-4-methoxypyridine

Basic Information

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CAS Number

880870-13-3

Molecular Formula

C6H5BrClNO

Molecular Weight

222.47 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

251°C at 760 mmHg

Density

1.650

Flash Point

105℃

SMILES

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COc1cc(Cl)ncc1Br

InChI

InChI=1S/C6H5BrClNO/c1-10-5-2-6(8)9-3-4(5)7/h2-3H,1H3

InChIKey

UUWWGXPWPZJEMG-UHFFFAOYSA-N

LogP

2.506100000000001

Topological Polar Surface Area

22.12 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

114

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

5-Bromo-2-chloro-4-methoxypyridine
Pyridine, 5-bromo-2-chloro-4-methoxy-
UUWWGXPWPZJEMG-UHFFFAOYSA-N
4039AC
FCH1395568
AX8212713
ST24044417
AK00742948
5-Bromo-2-chloro-4-methoxypyridine (ACI)

MDL Number

MFCD09909843

FAQ

What are the physical and chemical properties of 5-Bromo-2-chloro-4-methoxypyridine (CAS: 880870-13-3)?

5-Bromo-2-chloro-4-methoxypyridine is a crystalline solid with a molecular weight of approximately 254.01 g/mol. It has a low water solubility and is slightly soluble in common organic solvents like ethanol and acetone. This compound is known for its reactivity, particularly towards nucleophilic substitution reactions. It is commonly used in organic synthesis and pharmaceuticals.

How is 5-Bromo-2-chloro-4-methoxypyridine (CAS: 880870-13-3) typically synthesized?

5-Bromo-2-chloro-4-methoxypyridine can be synthesized through a series of reactions starting from 2-chloro-4-methoxypyridine. The bromination of 2-chloro-4-methoxypyridine is the key step, which can be achieved using bromine in the presence of a suitable base like sodium hydroxide. The reaction is typically performed in a suitable solvent like acetic acid, yielding a high yield of the target compound with good selectivity.

What industries use 5-Bromo-2-chloro-4-methoxypyridine (CAS: 880870-13-3)?

5-Bromo-2-chloro-4-methoxypyridine is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It is also utilized in the polymer industry for the development of functional polymers, and in the semiconductor industry for the production of organic semiconductors. Additionally, it has applications in the sensor industry for the development of gas sensors.

What precautions should be taken when handling 5-Bromo-2-chloro-4-methoxypyridine (CAS: 880870-13-3)?

When handling 5-Bromo-2-chloro-4-methoxypyridine, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a fume hood to minimize exposure to vapors. In case of a spill, the area should be immediately cleaned up using appropriate absorbent materials, and the spill area should be decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.