How is 5-Bromo-2-chloro-4-methoxypyridine (CAS: 880870-13-3) typically synthesized?

5-Bromo-2-chloro-4-methoxypyridine can be synthesized through a series of reactions starting from 2-chloro-4-methoxypyridine. The bromination of 2-chloro-4-methoxypyridine is the key step, which can be achieved using bromine in the presence of a suitable base like sodium hydroxide. The reaction is typically performed in a suitable solvent like acetic acid, yielding a high yield of the target compound with good selectivity.