5-Bromo-2-chloro-4-methoxypyridine(CAS: 880870-13-3)

5-Bromo-2-chloro-4-methoxypyridine is a crystalline solid with a molecular weight of approximately 254.01 g/mol. It has a low water solubility and is slightly soluble in common organic solvents like ethanol and acetone. This compound is known for its reactivity, particularly towards nucleophilic substitution reactions. It is commonly used in organic synthesis and pharmaceuticals.

5-Bromo-2-chloro-4-methoxypyridine can be synthesized through a series of reactions starting from 2-chloro-4-methoxypyridine. The bromination of 2-chloro-4-methoxypyridine is the key step, which can be achieved using bromine in the presence of a suitable base like sodium hydroxide. The reaction is typically performed in a suitable solvent like acetic acid, yielding a high yield of the target compound with good selectivity.

5-Bromo-2-chloro-4-methoxypyridine is primarily used in the pharmaceutical industry for the synthesis of various medicinal compounds. It is also utilized in the polymer industry for the development of functional polymers, and in the semiconductor industry for the production of organic semiconductors. Additionally, it has applications in the sensor industry for the development of gas sensors.

When handling 5-Bromo-2-chloro-4-methoxypyridine, it is crucial to wear appropriate personal protective equipment (PPE) such as gloves, safety goggles, and a lab coat. The compound should be handled in a fume hood to minimize exposure to vapors. In case of a spill, the area should be immediately cleaned up using appropriate absorbent materials, and the spill area should be decontaminated. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.