4-Methyl-2-(trifluoromethyl)aniline

Basic Information

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CAS Number

87617-23-0

Molecular Formula

C8H8F3N

Molecular Weight

175.15 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

SMILES

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CC1=CC(=C(C=C1)N)C(F)(F)F

InChI

InChI=1S/C8H8F3N/c1-5-2-3-7(12)6(4-5)8(9,10)11/h2-4H,12H2,1H3

InChIKey

JPPWLYYUBCTQMY-UHFFFAOYSA-N

LogP

2.59602

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

155

Safety Information

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Hazard Statement

Synonyms & References

English

CL9148
4-methyl-2-(trifluoromethyl)benzenamine
FT-0611177
CS-0169344
4-methyl-2-trifluoromethylaniline
J-511017
AS-46224
AKOS006228370
87617-23-0
4-methyl-2-trifluoromethyl-phenylamine
4-methyl-2-trifluoromethylphenylamine
AC-6877
Benzenamine, 4-methyl-2-(trifluoromethyl)-
DTXSID70372221
2-Amino-5-methylbenzotrifluoride
SCHEMBL184870
3-(TRIFLUOROMETHYL)-4-AMINO-TOLUENE
4-methyl-2-(trifluoromethyl)aniline
2-trifluoromethyl-4-methylaniline
EN300-103742
MFCD01631581
4-Methyl-2-(trifluoromethyl)aniline
2-AMINO-5-METHYLBENZOTRIFLUORIDE
4-methyl-2-(trifluoromethyl)phenylamine
PubChem2775
JPPWLYYUBCTQMY-UHFFFAOYSA-N
4-methyl-2-trifluoromethyl-aniline
SBB089011
AKO
4-Methyl-2-(trifluoromethyl)benzenamine (ACI)

MDL Number

MFCD01631581

Customs Code

2921430090

FAQ

What are the physical and chemical properties of 4-Methyl-2-(trifluoromethyl)aniline (CAS: 87617-23-0)?

4-Methyl-2-(trifluoromethyl)aniline is a white to off-white crystalline solid. Its molecular weight is approximately 210.07 g/mol. It is slightly soluble in water but soluble in organic solvents such as benzene and dichloromethane. It is known for its low reactivity under normal conditions but can undergo electrophilic aromatic substitution reactions under appropriate conditions.

How is 4-Methyl-2-(trifluoromethyl)aniline (CAS: 87617-23-0) typically synthesized?

4-Methyl-2-(trifluoromethyl)aniline can be synthesized through the nitration of 4-methyl-2-methoxybenzene followed by reduction of the nitro group to an amino group. The reaction is typically catalyzed by sulfuric acid and performed in the presence of water. The yield ranges from 70% to 80%, and the process involves careful control of temperature and reagent concentration to ensure selectivity.

What industries use 4-Methyl-2-(trifluoromethyl)aniline (CAS: 87617-23-0)?

4-Methyl-2-(trifluoromethyl)aniline is primarily used in the pharmaceutical industry as an intermediate for the synthesis of various drug molecules. It also finds application in the polymer industry for the production of certain types of plastics and in the sensor industry for the development of chemical sensors due to its fluorinated substituent.

What precautions should be taken when handling 4-Methyl-2-(trifluoromethyl)aniline (CAS: 87617-23-0)?

When handling 4-Methyl-2-(trifluoromethyl)aniline, it is important to wear appropriate personal protective equipment (PPE) including gloves, goggles, and a laboratory coat. Ensure the use of a fume hood to control the release of vapors. Spills should be handled with appropriate absorbent materials, and the area should be well-ventilated. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.