5-Amino-2-fluorophenylboronic acid

Basic Information

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CAS Number

873566-74-6

Molecular Formula

C6H7BFNO2

Molecular Weight

154.94 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

SMILES

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B(C1=C(C=CC(=C1)N)F)(O)O

InChI

InChI=1S/C6H7BFNO2/c8-6-2-1-4(9)3-5(6)7(10)11/h1-3,10-11H,9H2

InChIKey

CDZMVORRMKESPD-UHFFFAOYSA-N

LogP

-0.9123000000000003

Topological Polar Surface Area

66.48 Å²

Hydrogen Bond Donor/Acceptor

4 / 3

Complexity

136

Synonyms & References

English

(5-Amino-2-fluorophenyl)boronic acid
5-Amino-2-fluorophenylboronic acid
Boronic acid,B-(5-amino-2-fluorophenyl)-
B-(5-Amino-2-fluorophenyl)boronic acid (ACI)
Boronic acid, (5-amino-2-fluorophenyl)- (9CI)
2-Fluoro-5-aminophenylboronic acid
AT21959
2-fluoro-5-aminophenyl boronic acid
CS-0174872
AKOS006333033
SCHEMBL2786252
(5-amino-2-fluoro-phenyl)boronic Acid
5-AMINO-2-FLUOROPHENYLBORONIC ACID
MFCD03411555
(5-amino-2-fluorophenyl)boronic acid
2-fluoro-5-aminophenylboronic acid
BS-22556
DTXSID50405526
(5-amino-2-fluorophenyl)boronicacid
EN300-2991191
Boronic acid, (5-amino-2-fluorophenyl)-
873566-74-6

MDL Number

MFCD03411555

FAQ

What are the physical and chemical properties of 5-Amino-2-fluorophenylboronic acid (CAS: 873566-74-6)?

5-Amino-2-fluorophenylboronic acid is a white or pale yellow crystalline solid with a molecular weight of approximately 247.06 g/mol. It has a solubility of about 2.5 g/L in water at 25°C. The compound is moderately reactive and can undergo substitution reactions. It is also stable under normal conditions but should be stored in a dry environment to prevent hydrolysis.

How is 5-Amino-2-fluorophenylboronic acid (CAS: 873566-74-6) typically synthesized?

5-Amino-2-fluorophenylboronic acid is typically synthesized through a multistep procedure involving the protection of a phenol, followed by a substitution reaction with a boronic acid derivative. Common reagents include boronic acids, catalysts like palladium(II) acetate and triphenylphosphine, and a base such as triethylamine. The yield is generally around 70-80%.

What industries use 5-Amino-2-fluorophenylboronic acid (CAS: 873566-74-6)?

5-Amino-2-fluorophenylboronic acid is primarily used in the pharmaceutical industry for the synthesis of various organic compounds and intermediates. It also finds applications in the polymer industry for the development of new materials and in the semiconductor industry for the fabrication of electronic devices.

What precautions should be taken when handling 5-Amino-2-fluorophenylboronic acid (CAS: 873566-74-6)?

When handling 5-Amino-2-fluorophenylboronic acid, it is important to use gloves and protective eyewear to prevent skin and eye contact. The compound should be stored in a cool, dry place away from direct sunlight. In the event of a spill, it should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.