5-Amino-2-fluorophenylboronic acid(CAS: 873566-74-6)

5-Amino-2-fluorophenylboronic acid is a white or pale yellow crystalline solid with a molecular weight of approximately 247.06 g/mol. It has a solubility of about 2.5 g/L in water at 25°C. The compound is moderately reactive and can undergo substitution reactions. It is also stable under normal conditions but should be stored in a dry environment to prevent hydrolysis.

5-Amino-2-fluorophenylboronic acid is typically synthesized through a multistep procedure involving the protection of a phenol, followed by a substitution reaction with a boronic acid derivative. Common reagents include boronic acids, catalysts like palladium(II) acetate and triphenylphosphine, and a base such as triethylamine. The yield is generally around 70-80%.

5-Amino-2-fluorophenylboronic acid is primarily used in the pharmaceutical industry for the synthesis of various organic compounds and intermediates. It also finds applications in the polymer industry for the development of new materials and in the semiconductor industry for the fabrication of electronic devices.

When handling 5-Amino-2-fluorophenylboronic acid, it is important to use gloves and protective eyewear to prevent skin and eye contact. The compound should be stored in a cool, dry place away from direct sunlight. In the event of a spill, it should be cleaned up using appropriate absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed safety information.