(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid | CAS No. 854056-07-8

(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid

Basic Information

CAS Number

854056-07-8

Molecular Formula

C18H30N2O4S

Molecular Weight

370.52 g/mol

AD

Basic Physical Properties

Physical State

Powder

CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.CS(=O)(=O)O

InChI

InChI=1S/C17H26N2O.CH4O3S/c1-4-11-19-12-6-5-10-15(19)17(20)18-16-13(2)8-7-9-14(16)3;1-5(2,3)4/h7-9,15H,4-6,10-12H2,1-3H3,(H,18,20);1H3,(H,2,3,4)/t15-;/m0./s1

InChIKey

YPTSIOMXZOPKAF-RSAXXLAASA-N

LogP

3.010440000000001

Topological Polar Surface Area

86.71000000000001 Ų

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

401

Synonyms & References

English

  • (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide;methanesulfonic acid
  • Ropivacaine methanesulfonate
  • ROPIVACAINE MESYLATE [WHO-DD]
  • D83157
  • UNII-MJO2D2C5RI
  • Ropivacaine (mesylate)
  • DS-12083
  • EN300-7387212
  • CS-0099282
  • AC-6977
  • (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide; methanesulfonic acid
  • Q-100860
  • Ropivacaine mesylate
  • (2S)-N-(2,6-DIMETHYLPHENYL)-1-PROPYL-2-PIPERIDINECARBOXAMIDE MONOMETHANESULFONATE
  • SCHEMBL4880164
  • HY-B0563C
  • Ropivacaine Mesilate
  • (S)-N-(2,6-Dimethylphenyl)-1-propylpiperidine-2-carboxamide methanesulfonate
  • MJO2D2C5RI
  • HMS3886E15
  • 854056-07-8
  • AKOS015897310
  • Q27284072
  • (2S)-N-(2,6-Dimethylphenyl)-1-propyl-2-piperidinecarboxamide monomethanesulfonate
  • Ropivacaine Mesylate API
  • C17H26N2O.CH4O3S
  • EBD6814
  • API0007267
  • M57R954
  • M881

MDL Number

MFCD08458442

Customs Code

2942000000

FAQ

What are the physical and chemical properties of (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid (CAS: 854056-07-8)?

(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid is a crystalline compound with a molecular weight of approximately 338.41 g/mol. It has a solubility in water of 1.2 g/L at 25°C. The compound exhibits low reactivity under normal conditions but can undergo hydrolysis in basic conditions. It is typically used in pharmaceutical applications due to its physicochemical properties.

How is (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid (CAS: 854056-07-8) typically synthesized?

(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid is synthesized via a multi-step process, including the synthesis of N-(2,6-dimethylphenyl)-1-propylpiperidine followed by methanesulfonic acid esterification. Common reagents include methanesulfonyl chloride and a catalytic amount of triethylamine. The process yields up to 90% by weight, with high selectivity to the desired enantiomer.

What industries use (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid (CAS: 854056-07-8)?

(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid is widely used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry for the production of functionalized polymers. Additionally, it is utilized in the development of sensors and as a reagent in the semiconductor industry for specific chemical processes.

What precautions should be taken when handling (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid (CAS: 854056-07-8)?

When handling (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be performed in a fume hood to minimize inhalation risks. Spills should be contained and cleaned up using appropriate absorbents. Refer to the safety data sheet (SDS) for detailed emergency response procedures and storage guidelines. This compound is not highly toxic but should be handled with care due to its crystalline and potentially reactive nature.

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