(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid(CAS: 854056-07-8)

(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid is a crystalline compound with a molecular weight of approximately 338.41 g/mol. It has a solubility in water of 1.2 g/L at 25°C. The compound exhibits low reactivity under normal conditions but can undergo hydrolysis in basic conditions. It is typically used in pharmaceutical applications due to its physicochemical properties.

(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid is synthesized via a multi-step process, including the synthesis of N-(2,6-dimethylphenyl)-1-propylpiperidine followed by methanesulfonic acid esterification. Common reagents include methanesulfonyl chloride and a catalytic amount of triethylamine. The process yields up to 90% by weight, with high selectivity to the desired enantiomer.

(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid is widely used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the polymer industry for the production of functionalized polymers. Additionally, it is utilized in the development of sensors and as a reagent in the semiconductor industry for specific chemical processes.

When handling (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be performed in a fume hood to minimize inhalation risks. Spills should be contained and cleaned up using appropriate absorbents. Refer to the safety data sheet (SDS) for detailed emergency response procedures and storage guidelines. This compound is not highly toxic but should be handled with care due to its crystalline and potentially reactive nature.