Compound Q&A
How is (2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid (CAS: 854056-07-8) typically synthesized?
Answer
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid is synthesized via a multi-step process, including the synthesis of N-(2,6-dimethylphenyl)-1-propylpiperidine followed by methanesulfonic acid esterification. Common reagents include methanesulfonyl chloride and a catalytic amount of triethylamine. The process yields up to 90% by weight, with high selectivity to the desired enantiomer.
About
CAS No
854056-07-8
English Name
(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide, methanesulfonic acid
Molecular Formula
C18H30N2O4S
Molecular Weight
370.52 g/mol
SMILES
CCCN1CCCCC1C(=O)NC2=C(C=CC=C2C)C.CS(=O)(=O)O
InChIKey
YPTSIOMXZOPKAF-RSAXXLAASA-N
Last Updated: 2025-09-28 13:06
