2-Chloro-5-Fluoropyridine-3-carbaldehyde

Basic Information

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CAS Number

851484-95-2

Molecular Formula

C6H3ClFNO

Molecular Weight

159.55 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Aldehydes

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

224.378°C at 760 mmHg

Density

1.444

Flash Point

89.501°C

Refractive Index

1.565

SMILES

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C1=C(C=NC(=C1C=O)Cl)F

InChI

InChI=1S/C6H3ClFNO/c7-6-4(3-10)1-5(8)2-9-6/h1-3H

InChIKey

IMQFWCDQEAIYJV-UHFFFAOYSA-N

LogP

1.6866

Topological Polar Surface Area

29.96 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

133

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

2-Chloro-5-fluoropyridine-3-carbaldehyde
2-Chloro-5-fluoronicotinaldehyde
2-CHLORO-5-FLUORO-3-FORMYLPYRIDINE
2-chloro-5-fluoro-3-Pyridinecarboxaldehyde
2-Chloro-5-fluoro-pyridine-3-carbaldehyde
3-Pyridinecarboxaldehyde,2-chloro-5-fluoro-
2-chloro-5-fluoro-3-pyridinecarbaldehyde
2-chloro-5-fluoropyridine-3-carboxaldehyde
3-PYRIDINECARBOXALDEHYDE, 2-CHLORO-5-FLUORO-
PubChem17053
IMQFWCDQEAIYJV-UHFFFAOYSA-N
STL555650
FCH846924
BBL101853
V
2-chloro-5-fluoropyridine-3-carbaldehyde
SCHEMBL2119952
J-508829
851484-95-2
2-Chloro-5-Fluoropyridine-3-carbaldehyde
EN300-1719649
DB-024972
2-chloro-5-fluoronicotinaldehyde
2-Chloro-5-fluoro-3-formylpyridine
DTXSID70640093
AS-42550
AKOS006275786
AC-33403
MFCD03095247
2-CHLORO-5-FLUORO-3-PYRIDINECARBALDEHYDE
2-CHLORO-5-FLUOROPYRIDINE-3-CARBOXALDEHYDE

MDL Number

MFCD03095247

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Chloro-5-Fluoropyridine-3-carbaldehyde (CAS: 851484-95-2)?

2-Chloro-5-Fluoropyridine-3-carbaldehyde (CAS: 851484-95-2) is a crystalline compound with a molecular weight of approximately 206.03 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. The compound is known for its reactivity, particularly in nucleophilic aromatic substitution reactions. It is a solid at room temperature and has a characteristic odor.

How is 2-Chloro-5-Fluoropyridine-3-carbaldehyde (CAS: 851484-95-2) typically synthesized?

2-Chloro-5-Fluoropyridine-3-carbaldehyde is typically synthesized via the acylation of 2-chloro-5-fluoropyridine with acetaldehyde in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction is carried out under reflux, and high yields (up to 80%) can be achieved under optimized conditions. The reaction is highly selective and produces a single product with good purity.

What industries use 2-Chloro-5-Fluoropyridine-3-carbaldehyde (CAS: 851484-95-2)?

2-Chloro-5-Fluoropyridine-3-carbaldehyde (CAS: 851484-95-2) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the chemical industry for the development of novel materials and sensors. Additionally, it is used in the preparation of organofluorine compounds and as a reagent in organic chemistry research.

What precautions should be taken when handling 2-Chloro-5-Fluoropyridine-3-carbaldehyde (CAS: 851484-95-2)?

When handling 2-Chloro-5-Fluoropyridine-3-carbaldehyde (CAS: 851484-95-2), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be handled carefully using absorbent materials and cleaned up promptly. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.