2-Chloro-5-Fluoropyridine-3-carbaldehyde(CAS: 851484-95-2)

2-Chloro-5-Fluoropyridine-3-carbaldehyde (CAS: 851484-95-2) is a crystalline compound with a molecular weight of approximately 206.03 g/mol. It has a low solubility in water but is more soluble in organic solvents such as ethanol and acetone. The compound is known for its reactivity, particularly in nucleophilic aromatic substitution reactions. It is a solid at room temperature and has a characteristic odor.

2-Chloro-5-Fluoropyridine-3-carbaldehyde is typically synthesized via the acylation of 2-chloro-5-fluoropyridine with acetaldehyde in the presence of a Lewis acid catalyst, such as aluminum chloride. The reaction is carried out under reflux, and high yields (up to 80%) can be achieved under optimized conditions. The reaction is highly selective and produces a single product with good purity.

2-Chloro-5-Fluoropyridine-3-carbaldehyde (CAS: 851484-95-2) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It also finds applications in the chemical industry for the development of novel materials and sensors. Additionally, it is used in the preparation of organofluorine compounds and as a reagent in organic chemistry research.

When handling 2-Chloro-5-Fluoropyridine-3-carbaldehyde (CAS: 851484-95-2), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be used in a well-ventilated area or a fume hood to minimize exposure to vapors. Spills should be handled carefully using absorbent materials and cleaned up promptly. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions and emergency procedures.