![N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure](https://static.chemtradehub.com/structs/101/1013920-15-4-a4c8.webp "N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide structure")
N-[(3S)-1-(Dimethylcarbamoyl)-3-pyrrolidinyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide
CAS Number:
1013920-15-4
Molecular Formula:
C23H26FN5O3
5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole | CAS No. 850375-27-8
5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole
Basic Information
CAS Number
850375-27-8
Molecular Formula
C11H7BrF3NS
Molecular Weight
322.15 g/mol
AD
Chemical Classification
Basic Physical Properties
Safety Information
View Safety InformationSensitiveness
Stench
Synonyms & References
English
- Thiazole,5-bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-
- 5-Bromo-4-methyl-2-[4-(trifluoromethyl)-phenyl]-1,3-thiazole
- 5-BROMO-4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOLE
MDL Number
MFCD04974053
Customs Code
2934100090
FAQ
What are the physical and chemical properties of 5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (CAS: 850375-27-8)?
5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole is a crystalline solid with a molecular weight of approximately 349.02 g/mol. It has a high melting point and is slightly soluble in common organic solvents. The compound is reactive towards nucleophiles and can undergo substitution reactions. It is stable under normal storage conditions but should be protected from moisture and heat.
How is 5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (CAS: 850375-27-8) typically synthesized?
5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole can be synthesized through a multi-step process involving Friedel-Crafts alkylation, bromination, and thiazole formation. Commonly, a mixture of anisole, trifluoromethylbenzene, benzyl bromide, and thioacetamide is used as starting materials. The reaction conditions include the use of Lewis acids as catalysts and appropriate solvents to achieve high yield and selectivity.
What industries use 5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (CAS: 850375-27-8)?
5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole finds application in pharmaceuticals, where it serves as an intermediate in the synthesis of drugs. It is also used in the development of sensors and semiconductors due to its unique electronic properties. The compound's stability and reactivity make it a valuable tool in polymer chemistry for functionalizing materials.
What precautions should be taken when handling 5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (CAS: 850375-27-8)?
When handling 5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a well-ventilated area, away from heat sources and flammable materials. In case of a spill, use appropriate spill kits and follow safety data sheet (SDS) guidelines for clean-up. Always work in a fume hood to minimize exposure and inhalation risks.
Related Compounds
![7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure](https://static.chemtradehub.com/structs/101/1016505-59-1-4c54.webp "7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid structure")
7-Methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
CAS Number:
1016505-59-1
Molecular Formula:
C8H7N3O2
![2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure](https://static.chemtradehub.com/structs/104/1048919-15-8-ba81.webp "2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid structure")
2-Fluoro-6-({[(2-methyl-2-propanyl)oxy]carbonyl}amino)benzoic acid
CAS Number:
1048919-15-8
Molecular Formula:
C12H14FNO4
1,5,8-Trihydroxy-3-methoxy-2-(3-methyl-2-buten-1-yl)-9H-xanthen-9-one
CAS Number:
110187-11-6
Molecular Formula:
C19H18O6
![9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure](https://static.chemtradehub.com/structs/119/1198286-24-6-4781.webp "9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride structure")
9-Benzyl-2,9-diazaspiro[5.5]undecane dihydrochloride
CAS Number:
1198286-24-6
Molecular Formula:
C16H26Cl2N2
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