Compound Q&A
How is 5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole (CAS: 850375-27-8) typically synthesized?
Answer
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5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole can be synthesized through a multi-step process involving Friedel-Crafts alkylation, bromination, and thiazole formation. Commonly, a mixture of anisole, trifluoromethylbenzene, benzyl bromide, and thioacetamide is used as starting materials. The reaction conditions include the use of Lewis acids as catalysts and appropriate solvents to achieve high yield and selectivity.
About
CAS No
850375-27-8
English Name
5-Bromo-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole
Molecular Formula
C11H7BrF3NS
Molecular Weight
322.15 g/mol
SMILES
Cc1c(sc(n1)c2ccc(cc2)C(F)(F)F)Br
InChIKey
BZCIYGNYGIKEEC-UHFFFAOYSA-N
Last Updated: 2026-03-16 17:23
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