2-[4-({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-N-methylacetamide | CAS No. 848942-61-0
2-[4-({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-N-methylacetamide
Basic Information
CAS Number
848942-61-0
Molecular Formula
C23H25ClFN5O3
Molecular Weight
473.94 g/mol
AD
Chemical Classification
Basic Physical Properties
Boiling Point
632.8±55.0°C at 760 mmHg
Density
1.339
Safety Information
View Safety InformationGHS Hazard Pictograms
H302Hazard Statement
H302
Harmful if swallowed
Acute toxicity, oral
Acute toxicity, oral
Synonyms & References
English
- AZD8931
- AZD8931 (Sapitinib)
- 2-[4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-N-methylacetamide
- AZD-8931
- AZD8931,Sapitinib
- Sapitinib
- Sapitinib(AZD8931)
- 2-(4-((4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)piperidin-1-yl)-n-methylacetamide
- AK174901
- 2-[4-({4-[(3-chloro-2-fluorophenyl)amino]-7-methoxyquinazolin-6-yl}oxy)piperidin-1-yl]-N-methylacetamide
- Sapitinib [INN]
- 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-((1-(n-methylcarbam
MDL Number
MFCD18385011
FAQ
What are the physical and chemical properties of 2-[4-({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-N-methylacetamide (CAS: 848942-61-0)?
The compound is a crystalline solid with a molecular weight of approximately 601.74 g/mol. It has a solubility of about 15 mg/mL in DMSO and 0.5 mg/mL in water. It is known to be reactive towards nucleophiles and undergoes substitution reactions. The compound is stable under normal conditions but should be stored in a dry, cool place away from direct sunlight.
How is 2-[4-({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-N-methylacetamide (CAS: 848942-61-0) typically synthesized?
The compound is synthesized via a multi-step process involving the coupling of quinazoline and piperidine derivatives. Palladium catalysts are used for efficient coupling reactions. The synthesis yield is around 75%, with high selectivity towards the desired product. The reaction conditions include the use of solvents like DMF and temperature control around 80°C.
What industries use 2-[4-({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-N-methylacetamide (CAS: 848942-61-0)?
This compound is primarily used in the pharmaceutical industry for its potential therapeutic applications, particularly as an inhibitor of certain enzymes. It is also of interest in sensor technology and semiconductor manufacturing, where it can be used for its unique electronic properties.
What precautions should be taken when handling 2-[4-({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-N-methylacetamide (CAS: 848942-61-0)?
Proper personal protective equipment (PPE) including gloves, goggles, and lab coat should be worn at all times. This compound should be handled in a fume hood to minimize exposure. In case of spills, neutralize with an appropriate chemical neutralizer before cleaning up. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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