2-[4-({4-[(3-Chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}oxy)-1-piperidinyl]-N-methylacetamide(CAS: 848942-61-0)

The compound is a crystalline solid with a molecular weight of approximately 601.74 g/mol. It has a solubility of about 15 mg/mL in DMSO and 0.5 mg/mL in water. It is known to be reactive towards nucleophiles and undergoes substitution reactions. The compound is stable under normal conditions but should be stored in a dry, cool place away from direct sunlight.

The compound is synthesized via a multi-step process involving the coupling of quinazoline and piperidine derivatives. Palladium catalysts are used for efficient coupling reactions. The synthesis yield is around 75%, with high selectivity towards the desired product. The reaction conditions include the use of solvents like DMF and temperature control around 80°C.

This compound is primarily used in the pharmaceutical industry for its potential therapeutic applications, particularly as an inhibitor of certain enzymes. It is also of interest in sensor technology and semiconductor manufacturing, where it can be used for its unique electronic properties.

Proper personal protective equipment (PPE) including gloves, goggles, and lab coat should be worn at all times. This compound should be handled in a fume hood to minimize exposure. In case of spills, neutralize with an appropriate chemical neutralizer before cleaning up. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.