6-Amino-4-{[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino}-7-ethoxy-3-quinolinecarbonitrile | CAS No. 848139-78-6
6-Amino-4-{[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino}-7-ethoxy-3-quinolinecarbonitrile
Basic Information
CAS Number
848139-78-6
Molecular Formula
C24H20ClN5O2
Molecular Weight
17.03 g/mol
AD
Chemical Classification
Basic Physical Properties
Safety Information
View Safety InformationGHS Hazard Pictograms
H302Hazard Statement
H302
Harmful if swallowed
Acute toxicity, oral
Acute toxicity, oral
Synonyms & References
English
- 3-Quinolinecarbonitrile,6-amino-4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-ethoxy-
- 6-Amino-4-((3-chloro-4-(pyridin-2-ylmethoxy)phenyl)amino)-7-ethoxyquinoline-3-carbonitrile
- 3-Quinolinecarbonitrile, 6-amino-4-[[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino]-7-ethoxy-
- 6-AMINO-4-((3-CHLORO-4-(PYRIDIN-2-YLMETHOXY)PHENYL)AMINO)-7-ETHOXYQUINOLINE-3-CARBONITRILE (HYDROCHLORIDE)
- 6-Amino-4-(3-Chloro-4-(Pyridin-2-Ylmethoxy)Phenylamino)-7-Ethoxyquinoline-3-Carbonitrile
- 6-amino-4-[3-chloro-4-(pyridin-2-ylmethoxy)anilino]-7-ethoxyquinoline-3-carbonitrile
- 6-Amino-4-[3-chloro-4-[(2-pyridinyl)methoxy]anilino]-3-cyano-7-ethoxyquinoline
- HKI272
- Neratinib Intermediate3
- 6-amino-4-{[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}-7-ethoxyquinoline-3-carbonitrile
- AK171390
- 6-amino-4-[3-chloro-4-(2-pyridylmethoxy)anilino]-7-ethoxy-quinoline-3-carbonitrile
- 6-Amino-4-{3-chloro-4-[(pyridin-2-yl)methoxy]anilino}-7-ethoxyquinoline-3-carbonitrile
- 3-Quinolinecarbonitrile,6-amino-4-[[3-
MDL Number
MFCD12032114
FAQ
What are the physical and chemical properties of 6-Amino-4-{[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino}-7-ethoxy-3-quinolinecarbonitrile (CAS: 848139-78-6)?
The compound has a crystalline form with a molecular weight of approximately 504.26 g/mol. It has limited water solubility, being slightly soluble in water. Chemically, it is reactive, particularly towards nucleophiles and can undergo substitution and elimination reactions. It is stable under normal conditions but should be protected from moisture and heat.
How is 6-Amino-4-{[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino}-7-ethoxy-3-quinolinecarbonitrile (CAS: 848139-78-6) typically synthesized?
It is synthesized through a multi-step process involving the reaction of a pyridine derivative with a phenol derivative under basic conditions, followed by alkylation and nitrile formation. The reaction requires careful control of temperature and pH to achieve the desired yield and selectivity.
What industries use 6-Amino-4-{[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino}-7-ethoxy-3-quinolinecarbonitrile (CAS: 848139-78-6)?
This compound is primarily used in the pharmaceutical industry for its potential as a bioactive compound. It may also have applications in electronic materials and sensors due to its optical and electronic properties.
What precautions should be taken when handling 6-Amino-4-{[3-chloro-4-(2-pyridinylmethoxy)phenyl]amino}-7-ethoxy-3-quinolinecarbonitrile (CAS: 848139-78-6)?
Proper personal protective equipment (PPE) such as gloves, goggles, and a lab coat should be worn. The compound should be handled in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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