Lamotrigine EP Impurity B and Lamotrigine EP Impurity C | CAS No. 84689-20-3
Lamotrigine EP Impurity B and Lamotrigine EP Impurity C
Basic Information
CAS Number
84689-20-3
Molecular Formula
C9H7Cl2N5
Molecular Weight
256.09 g/mol
AD
Basic Physical Properties
Synonyms & References
English
- 2-(2,3-Dichlorophenyl)-2-guanidinyliminoacetonitrile
- 2-(2,3-Dichlorphenyl)-2-(guanidinylimino)acetonitrile
- 2-(2,3-DICHLORPHENYL)-2-(GUANIDINIMINO)ACETONITRILE
- 2,3-dichlorobenzoyl cyanide amidinohydrazone
- (2,3-Dichlorophenyl)(guanidinylimino)acetonitrile
- N-carbamimidoyl-2,3-dichlorobenzohydrazonoyl cyanide
MDL Number
MFCD07369322
FAQ
What are the physical and chemical properties of Lamotrigine EP Impurity B and Lamotrigine EP Impurity C (CAS: 84689-20-3)?
Lamotrigine EP Impurity B and C are impurities found in the lamotrigine drug substance. They are white crystalline solids with a molecular weight of approximately 264.27 g/mol. Solubility in water is low, with a solubility of about 0.02 g/100 mL at 25°C. Both impurities are chemically inert and do not react with common reagents. They are stable under normal storage conditions and do not decompose under typical laboratory conditions.
How are Lamotrigine EP Impurity B and Lamotrigine EP Impurity C (CAS: 84689-20-3) typically synthesized?
Lamotrigine EP Impurity B and C are typically synthesized as by-products during the production of lamotrigine. Common synthetic methods include alkylation and reduction steps, often using reagents like propionyl chloride and sodium borohydride. The synthesis involves catalytic hydrogenation and alkyl halide substitution reactions. The purity and selectivity of these impurities can vary depending on the process conditions and the quality of starting materials.
What industries use Lamotrigine EP Impurity B and Lamotrigine EP Impurity C (CAS: 84689-20-3)?
Lamotrigine EP Impurity B and C are primarily used in the pharmaceutical industry. They are critical quality attributes for lamotrigine as a drug substance, and their presence must be controlled to ensure product quality. These impurities are also of interest in research and development, particularly in studies related to drug efficacy and safety. They may also have applications in analytical chemistry for quality control purposes.
What precautions should be taken when handling Lamotrigine EP Impurity B and Lamotrigine EP Impurity C (CAS: 84689-20-3)?
When handling Lamotrigine EP Impurity B and C (CAS: 84689-20-3), it is essential to use appropriate personal protective equipment (PPE) such as gloves and safety glasses. Work should be conducted in a well-ventilated area or a fume hood to prevent inhalation. Spills should be cleaned up using appropriate absorbent materials, and the area should be properly decontaminated. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures. Storage should be in a cool, dry place, away from direct sunlight.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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