(1S)-1-(2,4-difluorophenyl)ethan-1-amine

Basic Information

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CAS Number

845252-02-0

Molecular Formula

C8H9F2N

Molecular Weight

157.16 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

175.4℃ at 760 mmHg

SMILES

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Fc1ccc(c(c1)F)[C@@H](N)C

InChI

InChI=1S/C8H9F2N/c1-5(11)7-3-2-6(9)4-8(7)10/h2-5H,11H2,1H3/t5-/m0/s1

InChIKey

VBPKWFKAYDHOQW-YFKPBYRVSA-N

LogP

1.9844999999999997

Topological Polar Surface Area

26.02 Å²

Hydrogen Bond Donor/Acceptor

2 / 1

Complexity

129

Synonyms & References

English

(S)-1-(2,4-Difluorophenyl)ethanamine
(S)-1-(2,4-DIFLUOROPHENYL)ETHANAMINE HCl
(S)-1-(2,4-DIFLUOROPHENYL)ETHANAMINE-HCL
Benzenemethanamine, 2,4-difluoro-a-methyl-, (aS)-
(S)-1-(2,4-difluorophenyl)ethylamine
(1S)-1-(2,4-difluorophenyl)ethanamine
AMOT0849
VBPKWFKAYDHOQW-YFKPBYRVSA-N
(S)-1-(2,4-difluoro-phenyl)ethanamine
(S)-1-(2,4 difluorophenyl)-ethylamine
(S)-1-(2,4-difluoro-phenyl)-ethylamine
W8720
ST24026482
(1S)-1-(2,4-difluorophenyl
(1S)-1-(2,4-difluorophenyl)ethan-1-amine

MDL Number

MFCD06761834

FAQ

What are the physical and chemical properties of (1S)-1-(2,4-difluorophenyl)ethan-1-amine (CAS: 845252-02-0)?

(1S)-1-(2,4-Difluorophenyl)ethan-1-amine (CAS: 845252-02-0) is a colorless to white crystalline solid with a molecular weight of approximately 165.09 g/mol. It has a low solubility in water but is soluble in common organic solvents like ethanol and dichloromethane. This compound is known for its reactivity, particularly in nucleophilic substitution reactions.

How is (1S)-1-(2,4-difluorophenyl)ethan-1-amine (CAS: 845252-02-0) typically synthesized?

(1S)-1-(2,4-Difluorophenyl)ethan-1-amine can be synthesized through a multistep process involving the synthesis of 2,4-difluorophenyl chloroformate followed by condensation with ethylamine. The reaction requires conditions that favor the formation of the desired stereoisomer. The yield is generally moderate, around 70-80%, with high purity achievable through recrystallization.

What industries use (1S)-1-(2,4-difluorophenyl)ethan-1-amine (CAS: 845252-02-0)?

(1S)-1-(2,4-Difluorophenyl)ethan-1-amine is utilized in the pharmaceutical industry for the synthesis of drug intermediates. It also finds application in the polymer industry for modifying polymer properties, in the chemical sensor industry for developing gas sensors, and in the semiconductor industry for the production of photoresists and other materials.

What precautions should be taken when handling (1S)-1-(2,4-difluorophenyl)ethan-1-amine (CAS: 845252-02-0)?

When handling (1S)-1-(2,4-difluorophenyl)ethan-1-amine, always use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work in a fume hood to avoid inhalation risks. Spills should be cleaned up immediately with appropriate absorbents. Refer to the safety data sheet (SDS) for detailed information and emergency procedures. Ensure proper storage in a cool, dry place away from direct sunlight and incompatible substances.