(1S)-1-(2,4-difluorophenyl)ethan-1-amine(CAS: 845252-02-0)

(1S)-1-(2,4-Difluorophenyl)ethan-1-amine (CAS: 845252-02-0) is a colorless to white crystalline solid with a molecular weight of approximately 165.09 g/mol. It has a low solubility in water but is soluble in common organic solvents like ethanol and dichloromethane. This compound is known for its reactivity, particularly in nucleophilic substitution reactions.

(1S)-1-(2,4-Difluorophenyl)ethan-1-amine can be synthesized through a multistep process involving the synthesis of 2,4-difluorophenyl chloroformate followed by condensation with ethylamine. The reaction requires conditions that favor the formation of the desired stereoisomer. The yield is generally moderate, around 70-80%, with high purity achievable through recrystallization.

(1S)-1-(2,4-Difluorophenyl)ethan-1-amine is utilized in the pharmaceutical industry for the synthesis of drug intermediates. It also finds application in the polymer industry for modifying polymer properties, in the chemical sensor industry for developing gas sensors, and in the semiconductor industry for the production of photoresists and other materials.

When handling (1S)-1-(2,4-difluorophenyl)ethan-1-amine, always use appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work in a fume hood to avoid inhalation risks. Spills should be cleaned up immediately with appropriate absorbents. Refer to the safety data sheet (SDS) for detailed information and emergency procedures. Ensure proper storage in a cool, dry place away from direct sunlight and incompatible substances.