2-Chloro-4-ethoxypyrimidine

Basic Information

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CAS Number

83774-09-8

Molecular Formula

C6H7ClN2O

Molecular Weight

158.59 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

35 ºC

Boiling Point

279 ºC

Density

1.235

Flash Point

123 ºC

SMILES

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CCOc1ccnc(Cl)n1

InChI

InChI=1S/C6H7ClN2O/c1-2-10-5-3-4-8-6(7)9-5/h3-4H,2H2,1H3

InChIKey

PXTBPZQWBZWDFS-UHFFFAOYSA-N

LogP

1.5287

Topological Polar Surface Area

35.010000000000005 Å²

Hydrogen Bond Donor/Acceptor

0 / 3

Synonyms & References

English

2-Chloro-4-ethoxy-pyrimidine
2-CHLORO-4-ETHOXYPYRIMIDINE
C6H7ClN2O
2-chloro-4-ethoxypyrimidine(SALTDATA: FREE)

MDL Number

MFCD00234199

FAQ

What are the physical and chemical properties of 2-Chloro-4-ethoxypyrimidine (CAS: 83774-09-8)?

2-Chloro-4-ethoxypyrimidine (CAS: 83774-09-8) is a solid crystalline compound with a molecular weight of approximately 185.01 g/mol. It has a high solubility in organic solvents like dimethylformamide (DMF) and methanol. Chemically, it is reactive, particularly towards nucleophiles and can undergo substitution reactions. It is insoluble in water.

How is 2-Chloro-4-ethoxypyrimidine (CAS: 83774-09-8) typically synthesized?

2-Chloro-4-ethoxypyrimidine can be synthesized via the reaction of 4-ethoxypyrimidine with thionyl chloride in the presence of a solvent such as toluene. The process typically involves the formation of an intermediate which then undergoes further substitution to yield the target compound. The reaction is usually carried out at room temperature with good yield and selectivity.

What industries use 2-Chloro-4-ethoxypyrimidine (CAS: 83774-09-8)?

2-Chloro-4-ethoxypyrimidine (CAS: 83774-09-8) is used in the pharmaceutical industry for the synthesis of certain drugs. It also finds applications in the polymer industry for the development of specific polymers and in the semiconductor industry for sensor applications. Its reactivity makes it valuable in these areas.

What precautions should be taken when handling 2-Chloro-4-ethoxypyrimidine (CAS: 83774-09-8)?

When handling 2-Chloro-4-ethoxypyrimidine (CAS: 83774-09-8), it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be handled using appropriate spill kits, and the material safety data sheet (MSDS) should be consulted for detailed information on safe handling and disposal.