4-(3-Methoxyphenyl)-1,3-thiazol-2-amine

Basic Information

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CAS Number

83558-37-6

Molecular Formula

C10H10N2OS

Molecular Weight

206.27 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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COC1=CC=CC(=C1)C2=CSC(=N2)N

InChI

InChI=1S/C10H10N2OS/c1-13-8-4-2-3-7(5-8)9-6-14-10(11)12-9/h2-6H,1H3,(H2,11,12)

InChIKey

NUMMWUVARLSQFR-UHFFFAOYSA-N

LogP

2.4009

Topological Polar Surface Area

48.14 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

191

Safety Information

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Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

A848940
2-Amino-4-(3-methoxyphenyl)thiazole
AKOS000123784
VU0509215-1
EN300-236276
MS-10998
NUMMWUVARLSQFR-UHFFFAOYSA-N
DTXSID00352718
Z48847677
thiazol-2-amine, 11
F3099-0635
MFCD02663861
CHEMBL3410185
4-(3-methoxyphenyl)-1,3-thiazol-2-amine
AB12099
BDBM31181
4-(3-Methoxy-phenyl)-thiazol-2-ylamine
4-(3-Methoxyphenyl)thiazol-2-ylamine
83558-37-6
FT-0677808
SCHEMBL235435
4-(3-Methoxyphenyl)thiazol-2-amine
AM90133
4-(3-METHOXY PHENYL) THIAZOLE-2-AMINE
2-AMino-4-(3-Methoxyphenyl)thiazole
2-amino-4-m-methoxyphenylthiazole

MDL Number

MFCD02663861

Customs Code

2934100090

FAQ

What are the physical and chemical properties of 4-(3-Methoxyphenyl)-1,3-thiazol-2-amine (CAS: 83558-37-6)?

4-(3-Methoxyphenyl)-1,3-thiazol-2-amine (CAS: 83558-37-6) is a crystalline solid with a molecular weight of approximately 238.24 g/mol. It has a low solubility in water but is more soluble in organic solvents such as methanol and dimethylformamide. This compound is known for its moderate reactivity, particularly towards nucleophiles and electrophiles. It is stable under normal conditions but should be stored in a cool, dark place to avoid photodegradation.

How is 4-(3-Methoxyphenyl)-1,3-thiazol-2-amine (CAS: 83558-37-6) typically synthesized?

4-(3-Methoxyphenyl)-1,3-thiazol-2-amine (CAS: 83558-37-6) can be synthesized via a multi-step process involving the condensation of 2-aminobenzothiazole with 3-methoxyaniline. Common methods include the use of coupling reagents like 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) to enhance the coupling efficiency. The overall yield is typically around 70-80%, depending on the purity and conditions of the reactants.

What industries use 4-(3-Methoxyphenyl)-1,3-thiazol-2-amine (CAS: 83558-37-6)?

4-(3-Methoxyphenyl)-1,3-thiazol-2-amine (CAS: 83558-37-6) is primarily used in the pharmaceutical industry as a precursor for drug synthesis. It also finds applications in the polymer industry for the development of specialized polymer additives. Additionally, this compound has potential uses in the sensor and semiconductor industries due to its electronic properties.

What precautions should be taken when handling 4-(3-Methoxyphenyl)-1,3-thiazol-2-amine (CAS: 83558-37-6)?

When handling 4-(3-Methoxyphenyl)-1,3-thiazol-2-amine (CAS: 83558-37-6), it is essential to follow standard safety guidelines. Wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate materials, and the area should be thoroughly rinsed with water. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and storage procedures.