Hydrocortisone 11,21-Diacetate

Basic Information

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CAS Number

81968-66-3

Molecular Formula

C25H34O7

Molecular Weight

446.53 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

SMILES

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CC(=O)OCC(=O)[C@]1(CCC2C3CCC4=CC(=O)CC[C@]4(C)C3[C@H](C[C@@]21C)OC(=O)C)O

InChI

InChI=1S/C25H34O7/c1-14(26)31-13-21(29)25(30)10-8-19-18-6-5-16-11-17(28)7-9-23(16,3)22(18)20(32-15(2)27)12-24(19,25)4/h11,18-20,22,30H,5-10,12-13H2,1-4H3/t18?,19?,20-,22?,23-,24-,25-/m0/s1

InChIKey

IZCYHZAQYDURFA-AHLMTOPJSA-N

LogP

2.923200000000002

Topological Polar Surface Area

106.97000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Synonyms & References

English

Hydrocortisone Acetate EP Impurity G
2-((8S,9S,10R,11S,13S,14S,17R)-11-acetoxy-17-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate

FAQ

What are the physical and chemical properties of Hydrocortisone 11,21-Diacetate (CAS: 81968-66-3)?

Hydrocortisone 11,21-Diacetate is a white or off-white crystalline powder with a molecular weight of approximately 469.53 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. This compound is less reactive than other corticosteroids but exhibits some steroid-like properties. It is stable under standard storage conditions but should be protected from light and moisture.

How is Hydrocortisone 11,21-Diacetate (CAS: 81968-66-3) typically synthesized?

Hydrocortisone 11,21-Diacetate is typically synthesized by acetylation of hydrocortisone. The reaction involves treating hydrocortisone with acetic anhydride in the presence of a catalytic amount of acid, such as acetic acid. The process yields a higher molecular weight compound that enhances the stability of hydrocortisone, making it suitable for pharmaceutical applications.

What industries use Hydrocortisone 11,21-Diacetate (CAS: 81968-66-3)?

Hydrocortisone 11,21-Diacetate is primarily used in the pharmaceutical industry for the production of topical corticosteroid preparations. It is also utilized in the research and development of new steroid-based drugs. This compound is less commonly used in other industries such as polymers, sensors, and semiconductors due to its specific biological activity.

What precautions should be taken when handling Hydrocortisone 11,21-Diacetate (CAS: 81968-66-3)?

When handling Hydrocortisone 11,21-Diacetate, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or under a fume hood to prevent inhalation. Spills should be cleaned up using appropriate methodologies, and the material safety data sheet (MSDS) should be consulted for detailed spill procedures. Storage should be in a cool, dry place away from direct sunlight and heat sources.