Hydrocortisone 11,21-Diacetate(CAS: 81968-66-3)

Hydrocortisone 11,21-Diacetate is a white or off-white crystalline powder with a molecular weight of approximately 469.53 g/mol. It is poorly soluble in water but soluble in organic solvents like ethanol and acetone. This compound is less reactive than other corticosteroids but exhibits some steroid-like properties. It is stable under standard storage conditions but should be protected from light and moisture.

Hydrocortisone 11,21-Diacetate is typically synthesized by acetylation of hydrocortisone. The reaction involves treating hydrocortisone with acetic anhydride in the presence of a catalytic amount of acid, such as acetic acid. The process yields a higher molecular weight compound that enhances the stability of hydrocortisone, making it suitable for pharmaceutical applications.

Hydrocortisone 11,21-Diacetate is primarily used in the pharmaceutical industry for the production of topical corticosteroid preparations. It is also utilized in the research and development of new steroid-based drugs. This compound is less commonly used in other industries such as polymers, sensors, and semiconductors due to its specific biological activity.

When handling Hydrocortisone 11,21-Diacetate, it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be handled in a well-ventilated area or under a fume hood to prevent inhalation. Spills should be cleaned up using appropriate methodologies, and the material safety data sheet (MSDS) should be consulted for detailed spill procedures. Storage should be in a cool, dry place away from direct sunlight and heat sources.