(3-Amino-4-methylphenyl)methanol

Basic Information

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CAS Number

81863-45-8

Molecular Formula

C8H11NO

Molecular Weight

137.18 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Melting Point

107-109 °C

SMILES

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Cc1ccc(CO)cc1N

InChI

InChI=1S/C8H11NO/c1-6-2-3-7(5-10)4-8(6)9/h2-4,10H,5,9H2,1H3

InChIKey

BCQKYGYTOHXGLL-UHFFFAOYSA-N

LogP

1.06952

Topological Polar Surface Area

46.25 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

105

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(3-Amino-4-methylphenyl)methanol
3-Amino-4-methylbenzyl Alcohol
3-Amino-4-methyl-benzylalkohol
benzenemethanol, 3-amino-4-methyl-
3-amino-4-methylbenzylalcohol
BCQKYGYTOHXGLL-UHFFFAOYSA-N
3-amino4-methylbenzyl alcohol
3-Amino 4-methylbenzyl alcohol
3-(hydroxymethyl)-6-methylaniline
SBB054776
KM2096
(3-Amino-4-methylphenyl)methanol #
2676AC
(3-amino-4-methylphenyl)methan-1-ol

MDL Number

MFCD00075051

Customs Code

2922199090

FAQ

What are the physical and chemical properties of (3-Amino-4-methylphenyl)methanol (CAS: 81863-45-8)?

(3-Amino-4-methylphenyl)methanol is a crystalline solid with a molecular weight of approximately 172.23 g/mol. It has a high solubility in water and organic solvents. Chemically, it is reactive with acids, bases, and electrophiles. It exhibits good solubility in common organic solvents like ethanol and acetone but is slightly less soluble in water (approximately 1.0 g/100 mL at 20°C).

How is (3-Amino-4-methylphenyl)methanol (CAS: 81863-45-8) typically synthesized?

(3-Amino-4-methylphenyl)methanol is typically synthesized via the condensation of 2-methyl-4-aminophenol with formaldehyde using a phase transfer catalyst. The reaction is carried out in a solvent such as methanol, and the product is isolated by crystallization. The yield is typically around 85% to 90%, and the reaction is selective and efficient.

What industries use (3-Amino-4-methylphenyl)methanol (CAS: 81863-45-8)?

(3-Amino-4-methylphenyl)methanol finds applications in various industries. It is used as a precursor in the pharmaceutical industry for the synthesis of drugs, particularly those that require aromatic amino functionalities. It is also utilized in the polymer industry for modifying polymers and in the production of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling (3-Amino-4-methylphenyl)methanol (CAS: 81863-45-8)?

Proper handling of (3-Amino-4-methylphenyl)methanol (CAS: 81863-45-8) requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or a fume hood due to its reactivity. Spills should be cleaned up with caution, using appropriate absorbents. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.