5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine

Basic Information

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CAS Number

81246-80-2

Molecular Formula

C36H44N2O8Si

Molecular Weight

660.84 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.24±0.1 g/cm3 (20 ºC 760 Torr),

Solubility

Insuluble (3.5E-5 g/L) (25 ºC),

SMILES

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O=C1NC(C=CN1[C@@H]2O[C@H](COC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5)[C@@H](O)[C@H]2O[Si](C)(C(C)(C)C)C)=O

InChI

InChI=1S/C36H44N2O8Si/c1-35(2,3)47(6,7)46-32-31(40)29(45-33(32)38-22-21-30(39)37-34(38)41)23-44-36(24-11-9-8-10-12-24,25-13-17-27(42-4)18-14-25)26-15-19-28(43-5)20-16-26/h8-22,29,31-33,40H,23H2,1-7H3,(H,37,39,41)/t29-,31-,32-,33-/m1/s1

InChIKey

KVHQIELPHWJPSY-WXQJYUTRSA-N

LogP

5.211200000000005

Topological Polar Surface Area

121.24000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 10

Complexity

1070

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

5'-O-DMT-2'-TBDMS-Uridine
1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyld methylsilyl)oxy)-4-hydroxytetrahydrofu...
1-((2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-3-((tert-butyldimethylsilyl)oxy)-4-hydroxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione
2'-O-tert-Butyldimethylsilyl-5'-O-(4,4'-dimethoxytrityl)uridine
2'-O-TERT-BUTYLDIMETHYLSILYL-5'-O-DMT-URIDINE
5’-DMT-2’-TBDMS-rU
5'-DMT-2'-TBDMS-RU
2'-O-(tert-Butyldimethylsilyl)-5'-O-(4,4'-dimethoxytrityl)uridine
C36H44N2O8Si
2618AC
2'-O-tertButyldimethylsilyl-5'-O-DMT-uridine
3'-O-tert-Butyldimethylsilyl-5'-O-DMT-uridine
5'-O-(4,4'-Dimethoxytrity

MDL Number

MFCD00135726

FAQ

What are the physical and chemical properties of 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine (CAS: 81246-80-2)?

5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine has a crystalline form with a molecular weight of approximately 827.5 g/mol. It has moderate solubility in organic solvents like dichloromethane and poor solubility in water. This compound is reactive towards nucleophilic substitution and ester hydrolysis under certain conditions.

How is 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine (CAS: 81246-80-2) typically synthesized?

5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine is typically synthesized through a multi-step process involving derivatization of uridine. Key steps include protection of the hydroxyl group, introduction of the bicyclic structure, and silylation. Commonly used reagents include dimethyl(2-methyl-2-propanyl)silane and appropriate protecting groups. The overall yield is around 50-70%.

What industries use 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine (CAS: 81246-80-2)?

5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine is primarily used in pharmaceuticals for therapeutic and diagnostic applications. It is also explored in polymer science for the development of novel materials and in analytical chemistry for sensing and labeling purposes.

What precautions should be taken when handling 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine (CAS: 81246-80-2)?

When handling 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up with appropriate absorbent materials and disposed of according to laboratory safety guidelines. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.

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Compound Q&A

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5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine | CAS No. 81246-80-2

Basic Information

CAS Number

Molecular Formula

Molecular Weight

Chemical Classification

Basic Physical Properties

Density

Solubility

Chemical Properties

SMILES

InChI

InChIKey

LogP

Topological Polar Surface Area

Hydrogen Bond Donor/Acceptor

Complexity

Safety Information

Hazard Statement

Synonyms & References

English

MDL Number

FAQ

What are the physical and chemical properties of 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine (CAS: 81246-80-2)?

How is 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine (CAS: 81246-80-2) typically synthesized?

What industries use 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine (CAS: 81246-80-2)?

What precautions should be taken when handling 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine (CAS: 81246-80-2)?

Related Compounds

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