5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine(CAS: 81246-80-2)

5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine has a crystalline form with a molecular weight of approximately 827.5 g/mol. It has moderate solubility in organic solvents like dichloromethane and poor solubility in water. This compound is reactive towards nucleophilic substitution and ester hydrolysis under certain conditions.

5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine is typically synthesized through a multi-step process involving derivatization of uridine. Key steps include protection of the hydroxyl group, introduction of the bicyclic structure, and silylation. Commonly used reagents include dimethyl(2-methyl-2-propanyl)silane and appropriate protecting groups. The overall yield is around 50-70%.

5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine is primarily used in pharmaceuticals for therapeutic and diagnostic applications. It is also explored in polymer science for the development of novel materials and in analytical chemistry for sensing and labeling purposes.

When handling 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up with appropriate absorbent materials and disposed of according to laboratory safety guidelines. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.