Compound Q&A
How is 5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine (CAS: 81246-80-2) typically synthesized?
Answer
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine](https://static.chemtradehub.com/structs/812/81246-80-2-8676.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine is typically synthesized through a multi-step process involving derivatization of uridine. Key steps include protection of the hydroxyl group, introduction of the bicyclic structure, and silylation. Commonly used reagents include dimethyl(2-methyl-2-propanyl)silane and appropriate protecting groups. The overall yield is around 50-70%.
About
CAS No
81246-80-2
English Name
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]-2'-O-[dimethyl(2-methyl-2-propanyl)silyl]uridine
Molecular Formula
C36H44N2O8Si
Molecular Weight
660.84 g/mol
SMILES
O=C1NC(C=CN1[C@@H]2O[C@H](COC(C3=CC=C(OC)C=C3)(C4=CC=C(OC)C=C4)C5=CC=CC=C5)[C@@H](O)[C@H]2O[Si](C)(C(C)(C)C)C)=O
InChIKey
KVHQIELPHWJPSY-WXQJYUTRSA-N
Last Updated: 2025-10-20 00:35
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