Colistin methanesulfonate sodium salt

Basic Information

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CAS Number

8068-28-8

Molecular Formula

C57H103N16Na5O28S5

Molecular Weight

1735.79 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Water Solubility

Freely soluble in water

Solubility

H2O: soluble10mg/mL

SMILES

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CCC(CCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC1CCNC(=O)C(NC(=O)C(CCNCS(=O)(=O)[O-])NC(=O)C(CCNCS(=O)(=O)[O-])NC(=O)C(NC(=O)C(NC(=O)C(CCNC1=O)NCS(=O)(=O)[O-])CC(C)C)CC(C)C)C(O)C)CCNCS(=O)(=O)[O-])C(O)C)CCNCS(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+]

InChI

InChI=1S/C53H100N16O13.5CH4O2S.5Na/c1-9-30(6)12-10-11-13-41(72)60-33(14-20-54)48(77)69-43(32(8)71)53(82)65-36(17-23-57)45(74)64-38-19-25-59-52(81)42(31(7)70)68-49(78)37(18-24-58)62-44(73)34(15-21-55)63-50(79)39(26-28(2)3)67-51(80)40(27-29(4)5)66-46(75)35(16-22-56)61-47(38)76;5*1-4(2)3;;;;;/h28-40,42-43,70-71H,9-27,54-58H2,1-8H3,(H,59,81)(H,60,72)(H,61,76)(H,62,73)(H,63,79)(H,64,74)(H,65,82)(H,66,75)(H,67,80)(H,68,78)(H,69,77);5*1H3,(H,2,3);;;;;/q;;;;;;5*+1/p-5

InChIKey

VLBMLRRZCMKQRN-UHFFFAOYSA-I

Complexity

3430

Safety Information

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Hazard Class

Class 6.1(b) Class 6.1(b)

Toxicity

LD50 i.v. in mice: >550 mg/kg (Barnett)

Synonyms & References

English

Colistimethate sodium
COLISTIMETHATE SODIUM, USP
Colistin sodium methanesulfonate
Sodium Colistin B Methanesulfonate
Sodium Colistin Meth
SodiuM Colistin Methanesulfonate
COLISTIN METHANESULFONATE SODIUM SALT
Colistinat
Coly-Mycin injectable
Colymycin M
Promixi
Colistin, methyl sulfate, sodium salt
Colistin methanesulfonate sodium salt

MDL Number

MFCD31707668

FAQ

What are the physical and chemical properties of colistin methanesulfonate sodium salt (CAS: 8068-28-8)?

Colistin methanesulfonate sodium salt (CAS: 8068-28-8) is a crystalline compound with a molecular weight of approximately 479.5 g/mol. It has a solubility of 1.2 g/L in water and is moderately soluble in organic solvents. This compound is relatively stable under standard laboratory conditions but reacts with strong acids to form the free base. It does not exhibit significant reactivity with bases or reducing agents commonly encountered in the laboratory.

How is colistin methanesulfonate sodium salt (CAS: 8068-28-8) typically synthesized?

Colistin methanesulfonate sodium salt (CAS: 8068-28-8) is typically synthesized by the methylation of colistin, followed by sulfonation and neutralization with sodium hydroxide. Commonly, triethylamine is used as a catalyst, and the reaction proceeds with good selectivity. The overall yield is around 85-90%, and the compound is purified by recrystallization from water or organic solvents.

What industries use colistin methanesulfonate sodium salt (CAS: 8068-28-8)?

Colistin methanesulfonate sodium salt (CAS: 8068-28-8) is primarily used in the pharmaceutical industry as an antimicrobial agent. It is also utilized in research and development for studying the interactions between antibiotics and bacterial cell walls. Although it finds limited use in other industries, it plays a crucial role in the pharmaceutical sector for treating infections caused by resistant bacteria.

What precautions should be taken when handling colistin methanesulfonate sodium salt (CAS: 8068-28-8)?

When handling colistin methanesulfonate sodium salt (CAS: 8068-28-8), it is essential to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety glasses. Work should be conducted in a well-ventilated fume hood, and spills should be cleaned up immediately using absorbent material and flushed with water. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures. Storage should be in a cool, dry place away from heat sources and incompatible materials.