Colistin methanesulfonate sodium salt(CAS: 8068-28-8)

Colistin methanesulfonate sodium salt (CAS: 8068-28-8) is a crystalline compound with a molecular weight of approximately 479.5 g/mol. It has a solubility of 1.2 g/L in water and is moderately soluble in organic solvents. This compound is relatively stable under standard laboratory conditions but reacts with strong acids to form the free base. It does not exhibit significant reactivity with bases or reducing agents commonly encountered in the laboratory.

Colistin methanesulfonate sodium salt (CAS: 8068-28-8) is typically synthesized by the methylation of colistin, followed by sulfonation and neutralization with sodium hydroxide. Commonly, triethylamine is used as a catalyst, and the reaction proceeds with good selectivity. The overall yield is around 85-90%, and the compound is purified by recrystallization from water or organic solvents.

Colistin methanesulfonate sodium salt (CAS: 8068-28-8) is primarily used in the pharmaceutical industry as an antimicrobial agent. It is also utilized in research and development for studying the interactions between antibiotics and bacterial cell walls. Although it finds limited use in other industries, it plays a crucial role in the pharmaceutical sector for treating infections caused by resistant bacteria.

When handling colistin methanesulfonate sodium salt (CAS: 8068-28-8), it is essential to wear appropriate personal protective equipment (PPE), including gloves, lab coat, and safety glasses. Work should be conducted in a well-ventilated fume hood, and spills should be cleaned up immediately using absorbent material and flushed with water. Always refer to the safety data sheet (SDS) for detailed handling instructions and emergency procedures. Storage should be in a cool, dry place away from heat sources and incompatible materials.