Compound Q&A
How is colistin methanesulfonate sodium salt (CAS: 8068-28-8) typically synthesized?
Answer
Colistin methanesulfonate sodium salt (CAS: 8068-28-8) is typically synthesized by the methylation of colistin, followed by sulfonation and neutralization with sodium hydroxide. Commonly, triethylamine is used as a catalyst, and the reaction proceeds with good selectivity. The overall yield is around 85-90%, and the compound is purified by recrystallization from water or organic solvents.
About
CAS No
8068-28-8
English Name
Colistin methanesulfonate sodium salt
Molecular Formula
C57H103N16Na5O28S5
Molecular Weight
1735.79 g/mol
SMILES
CCC(CCCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC1CCNC(=O)C(NC(=O)C(CCNCS(=O)(=O)[O-])NC(=O)C(CCNCS(=O)(=O)[O-])NC(=O)C(NC(=O)C(NC(=O)C(CCNC1=O)NCS(=O)(=O)[O-])CC(C)C)CC(C)C)C(O)C)CCNCS(=O)(=O)[O-])C(O)C)CCNCS(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+]
InChIKey
VLBMLRRZCMKQRN-UHFFFAOYSA-I
Last Updated: 2025-10-10 12:21
