4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide | CAS No. 8013-10-3
4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide
Basic Information
CAS Number
8013-10-3
Molecular Formula
C9H9BrFNO2
Molecular Weight
262.08 g/mol
AD
Basic Physical Properties
Boiling Point
184 °C
Density
0.991 g/mL at 25 °C<br />1.027 g/mL at 25 °C
Refractive Index
n20/D 1.522<br />n20/D 1.5340(lit.)
Safety Information
View Safety InformationHazard Statement
H226
Flammable liquid and vapor
Flammable liquids
Flammable liquids
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Synonyms & References
English
- CADE OIL
- cade
- cade’
- cadeoilractified
- cadeoilrectified
- caparlem
- empyreumaticoilofjuniper
- essencedecade’(french)
- haarlemoil
- Cade'
- Cade [Italian]
- Cade' [Spanish]
- Cade oil (Juniperus oxycedrus L.)
- Caswell No. 516
- EPA Pesticide Chemical Code 067203
- Essence de cade'
- Essence de cade' [French]
- Harlem oil
- Holland balsam
- HSDB 1970
- Juniper tar
- Juniper tar oil
- Kadeoel
- Kadeoel [German]
- Kaparlem
- Oil of cade
- Oil of juniper tar
- Oils, cade
- Oils, ju
- 4-BROMO-2-FLUORO-N-METHOXY-N-METHYLBENZAMIDE
- n-methoxy-n-methyl 4-bromo-2-fluorobenzamide
FAQ
What are the physical and chemical properties of 4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide (CAS: 8013-10-3)?
4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide (CAS: 8013-10-3) is a crystalline solid with a molecular weight of approximately 285.03 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and acetonitrile. Chemically, it is reactive towards nucleophiles and can participate in electrophilic aromatic substitution reactions. It is also susceptible to base-catalyzed hydrolysis, making it important to control the pH during synthesis and storage.
How is 4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide (CAS: 8013-10-3) typically synthesized?
4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide (CAS: 8013-10-3) is typically synthesized through a multistep process involving bromination, fluorination, and amide formation. The bromination of an appropriate starting material is often achieved using N-bromosuccinimide (NBS) in an organic solvent like dichloromethane. Subsequent steps include protecting the functional groups and introducing the fluoro and methoxy substituents. The final amide formation is usually catalyzed by a strong base like dicyclohexylcarbodiimide (DCC) or N,N'-carbonyldiimidazole (CDI).
What industries use 4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide (CAS: 8013-10-3)?
4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide (CAS: 8013-10-3) is used in various industries, particularly in pharmaceutical research and development. It serves as a precursor in the synthesis of complex molecules and drugs. Additionally, it finds applications in the production of certain polymers, where its unique substituents can influence the material properties. Its use in sensor technologies and semiconductor manufacturing is also documented, though on a more specialized scale.
What precautions should be taken when handling 4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide (CAS: 8013-10-3)?
When handling 4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide (CAS: 8013-10-3), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to potential vapors. Spills should be cleaned up with caution, using appropriate absorbents, and followed by thorough cleaning with water. Always consult the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) for detailed information and emergency procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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