4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide(CAS: 8013-10-3)

4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide (CAS: 8013-10-3) is a crystalline solid with a molecular weight of approximately 285.03 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and acetonitrile. Chemically, it is reactive towards nucleophiles and can participate in electrophilic aromatic substitution reactions. It is also susceptible to base-catalyzed hydrolysis, making it important to control the pH during synthesis and storage.

4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide (CAS: 8013-10-3) is typically synthesized through a multistep process involving bromination, fluorination, and amide formation. The bromination of an appropriate starting material is often achieved using N-bromosuccinimide (NBS) in an organic solvent like dichloromethane. Subsequent steps include protecting the functional groups and introducing the fluoro and methoxy substituents. The final amide formation is usually catalyzed by a strong base like dicyclohexylcarbodiimide (DCC) or N,N'-carbonyldiimidazole (CDI).

4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide (CAS: 8013-10-3) is used in various industries, particularly in pharmaceutical research and development. It serves as a precursor in the synthesis of complex molecules and drugs. Additionally, it finds applications in the production of certain polymers, where its unique substituents can influence the material properties. Its use in sensor technologies and semiconductor manufacturing is also documented, though on a more specialized scale.

When handling 4-Bromo-2-fluoro-N-methoxy-N-methylbenzamide (CAS: 8013-10-3), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to potential vapors. Spills should be cleaned up with caution, using appropriate absorbents, and followed by thorough cleaning with water. Always consult the Material Safety Data Sheet (MSDS) or Safety Data Sheet (SDS) for detailed information and emergency procedures.