Benzyl pyrrolidine-2-carboxylate hydrochloride

Basic Information

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CAS Number

8008-94-4

Molecular Formula

C12H16ClNO2

Molecular Weight

241.71 g/mol

EINECS

283-895-2

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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Cl.O(CC1C=CC=CC=1)C(C1CCCN1)=O

InChI

1S/C12H15NO2.ClH/c14-12(11-7-4-8-13-11)15-9-10-5-2-1-3-6-10;/h1-3,5-6,11,13H,4,7-9H2;1H

InChIKey

NEDMOHHWRPHBAL-UHFFFAOYSA-N

LogP

1.9035999999999997

Topological Polar Surface Area

38.33 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

212

Synonyms & References

English

LICORICE EXTRACT
LICORICE EXTRACT PASTE
benzyl pyrrolidine-2-carboxylate hydrochloride
H-Pro-Obzl HCl
L-Proline, phenylmethyl ester, hydrochloride
H-D-Pro-OBzl*HCl
Benzyl L-prolinate HCl
ETHYL2,3-DIBROMOBUTYRATE
benzyl DL-prolinate hydrochloride
benzyl DL -prolinate hydrochloride
NSC71043
Benzyl pyrrolidine-2-carboxylate HCl
l-proline benzyl ester hydro-chloride
NSC197199
NE37647
LICORICE LIQUID EXTRACT
LIQUORICE EXTRACT
LICORICE ROOT
LICORICE ROOT FLUID EXTRACT
LICORICE ROOT POWDER
GLYCYRRHIZA GLABRA POWDER
GLYCYRRHIZA GLABRA ROOT POWDER
FEMA 2628
Lilorice Root Extract

EC Number

283-895-2

FAQ

What are the physical and chemical properties of Benzyl pyrrolidine-2-carboxylate hydrochloride (CAS: 8008-94-4)?

Benzyl pyrrolidine-2-carboxylate hydrochloride is a white to off-white crystalline solid with a molecular weight of approximately 251.29 g/mol. It has a solubility of 4.8 g/L in water and is slightly soluble in methanol. Chemically, it is slightly basic and can react with strong acids to form salts. It is stable under normal conditions but should be stored in a cool, dry place away from direct sunlight and moisture.

How is Benzyl pyrrolidine-2-carboxylate hydrochloride (CAS: 8008-94-4) typically synthesized?

Benzyl pyrrolidine-2-carboxylate hydrochloride is typically synthesized by the condensation of benzylamine and pyrrolidine-2-carboxylic acid, followed by the addition of hydrochloric acid to form the hydrochloride salt. This process involves the use of a catalyst such as 4-dimethylaminopyridine (DMAP) for better selectivity and yield, which is around 85-90%.

What industries use Benzyl pyrrolidine-2-carboxylate hydrochloride (CAS: 8008-94-4)?

Benzyl pyrrolidine-2-carboxylate hydrochloride is primarily used in the pharmaceutical industry for the synthesis of various drug intermediates. It is also utilized in the polymer industry for the production of certain types of polymers. Additionally, it can be used in the sensor and semiconductor industries for specific applications requiring its chemical properties.

What precautions should be taken when handling Benzyl pyrrolidine-2-carboxylate hydrochloride (CAS: 8008-94-4)?

When handling Benzyl pyrrolidine-2-carboxylate hydrochloride, personal protective equipment (PPE) such as gloves, safety glasses, and a lab coat should be worn. It should be handled in a well-ventilated area or a fume hood to avoid inhaling dust or vapors. Spills should be cleaned up immediately using appropriate methods, and the material safety data sheet (MSDS) should be consulted for detailed information on handling and storage.