3-Chloro-2-fluoro-4-iodopyridine

Basic Information

View in Editor

CAS Number

796851-05-3

Molecular Formula

C5H2ClFIN

Molecular Weight

257.43 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

254.8±35.0℃/760mmHg

SMILES

View in Editor

c1cnc(c(c1I)Cl)F

InChI

InChI=1S/C5H2ClFIN/c6-4-3(8)1-2-9-5(4)7/h1-2H

InChIKey

NPDICENVXROWJV-UHFFFAOYSA-N

LogP

2.4787

Topological Polar Surface Area

12.89 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

103

Safety Information

View Safety Information

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

3-Chloro-2-fluoro-4-iodopyridine
2-fluoro-3-chloro-4-Iodopyridine
AG-L-58926
CTK7C3550
FT-0682850
I02-4366
MolPort-019-930-706
Pyridine, 3-chloro-2-fluoro-4-iodo-
NPDICENVXROWJV-UHFFFAOYSA-N
9865AE
AK179189
3-chloro-2-fluoro-4-iodopyridine

MDL Number

MFCD16610366

FAQ

What are the physical and chemical properties of 3-Chloro-2-fluoro-4-iodopyridine (CAS: 796851-05-3)?

3-Chloro-2-fluoro-4-iodopyridine is a crystalline solid with a molecular weight of approximately 319.91 g/mol. It has low water solubility and is moderately soluble in common organic solvents like DMF and DMSO. This compound shows reactivity typical of aromatic compounds, including electrophilic aromatic substitution reactions. It is stable under normal storage conditions but should be protected from moisture and heat.

How is 3-Chloro-2-fluoro-4-iodopyridine (CAS: 796851-05-3) typically synthesized?

3-Chloro-2-fluoro-4-iodopyridine is typically synthesized via the Friedel-Crafts alkylation of 2-fluoro-4-chloropyridine with iodine in the presence of aluminum chloride as a catalyst. The reaction proceeds through electrophilic aromatic substitution, yielding the desired product with good selectivity and yield.

What industries use 3-Chloro-2-fluoro-4-iodopyridine (CAS: 796851-05-3)?

3-Chloro-2-fluoro-4-iodopyridine is used in various industries, particularly in pharmaceuticals for the development of certain antiviral compounds. It also has potential applications in the synthesis of sensors and semiconductors due to its unique electronic properties.

What precautions should be taken when handling 3-Chloro-2-fluoro-4-iodopyridine (CAS: 796851-05-3)?

When handling 3-Chloro-2-fluoro-4-iodopyridine, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation of fumes. Spills should be cleaned up using appropriate absorbent materials, and the area should be decontaminated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.