3-Chloro-2-fluoro-4-iodopyridine(CAS: 796851-05-3)

3-Chloro-2-fluoro-4-iodopyridine is a crystalline solid with a molecular weight of approximately 319.91 g/mol. It has low water solubility and is moderately soluble in common organic solvents like DMF and DMSO. This compound shows reactivity typical of aromatic compounds, including electrophilic aromatic substitution reactions. It is stable under normal storage conditions but should be protected from moisture and heat.

3-Chloro-2-fluoro-4-iodopyridine is typically synthesized via the Friedel-Crafts alkylation of 2-fluoro-4-chloropyridine with iodine in the presence of aluminum chloride as a catalyst. The reaction proceeds through electrophilic aromatic substitution, yielding the desired product with good selectivity and yield.

3-Chloro-2-fluoro-4-iodopyridine is used in various industries, particularly in pharmaceuticals for the development of certain antiviral compounds. It also has potential applications in the synthesis of sensors and semiconductors due to its unique electronic properties.

When handling 3-Chloro-2-fluoro-4-iodopyridine, it is essential to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be handled in a well-ventilated area or a fume hood to avoid inhalation of fumes. Spills should be cleaned up using appropriate absorbent materials, and the area should be decontaminated. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.