YM155 (Sepantronium Bromide)

Basic Information

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CAS Number

781661-94-7

Molecular Formula

C20H19BrN4O3

Molecular Weight

443.29 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC1=[N+](C2=C(N1CCOC)C(=O)C3=CC=CC=C3C2=O)CC4=NC=CN=C4.[Br-]

InChI

InChI=1S/C20H19N4O3.BrH/c1-13-23(9-10-27-2)17-18(24(13)12-14-11-21-7-8-22-14)20(26)16-6-4-3-5-15(16)19(17)25;/h3-8,11H,9-10,12H2,1-2H3;1H/q+1;/p-1

InChIKey

QBIYUDDJPRGKNJ-UHFFFAOYSA-M

LogP

-1.65190

Complexity

571

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

BCPP000007
SEPANTRONIUM BROMIDE [USAN]
CHEMBL2105734
HY-10194
3-(2-METHOXYETHYL)-2-METHYL-4,9-DIOXO-1-(PYRAZIN-2-YLMETHYL)NAPHTHO[2,3-D]IMIDAZOL-1-IUM BROMIDE
HMS3654A08
EX-A2187
J-514184
MLS006010288
DTXSID90228817
Z2037281428
BCP01864
3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide
SCHEMBL727997
1H-Naphth[2,3-d]imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(2-pyrazinylmethyl)-, bromide
SMR004701357
EN300-7406819
sepantronii bromidum
1H-Naphth(2,3-d)imidazolium, 4,9-dihydro-1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazinylmethyl)-, bromide
BDBM50468263
Sepantronium bromide [USAN:INN]
CS-0336
SEPANTRONIUM BROMIDE [JAN]
1-(2-METHOXYETHYL)-2-METHYL-4,9-DIOXO-3-((PYRAZIN-2-YL)METHYL)-4,9-DIHYDRO-1H-NAPHTHO(2,3-D)IMIDAZOLIUM BROMIDE
D10164
AS-17057
FT-0660380
781661-94-7
AMY10848
1-(2-methoxyethyl)-2-methyl-3-(pyrazin-2-ylmethyl)benzo[f]benzimidazol-3-ium-4,9-dione;bromide
s1130

MDL Number

MFCD11983133

FAQ

What is YM155 (CAS: 781661-94-7)?

YM155, also known as Sepantronium Bromide, is a small molecule inhibitor of nuclear export. It is a brominated derivative of BIBR 1532. The compound has a molecular formula of C22H22BrN5O3 and a molecular weight of approximately 476.35 g/mol. YM155 is characterized by its ability to inhibit the export of various proteins from the nucleus to the cytoplasm, which can disrupt cellular processes and be used for research purposes.

What are the main uses of YM155 (CAS: 781661-94-7)?

YM155 is primarily used in pharmaceutical research as an inhibitor of the nuclear export protein XPO1. It is used to study the effects of perturbing nuclear transport in cells, which can help in understanding and developing treatments for diseases including cancers. Its use is mainly confined to laboratory research and not for clinical applications.

Is YM155 (CAS: 781661-94-7) safe?

YM155 is safe when handled properly under laboratory conditions. However, it should be used with caution as it may cause skin irritation. Protective measures such as gloves and safety goggles are recommended. The compound is not for oral or dermal use and should be stored away from children and pets. Direct contact with the skin or ingestion should be avoided.

How should YM155 (CAS: 781661-94-7) be stored?

YM155 should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept at a temperature not exceeding 25°C. The compound should be protected from moisture and should be stored in a tightly sealed container. Proper ventilation should be ensured during handling to prevent inhalation risks. It is advisable to store YM155 in a locked cabinet to prevent unauthorized access.