YM155 (Sepantronium Bromide)(CAS: 781661-94-7)

YM155, also known as Sepantronium Bromide, is a small molecule inhibitor of nuclear export. It is a brominated derivative of BIBR 1532. The compound has a molecular formula of C22H22BrN5O3 and a molecular weight of approximately 476.35 g/mol. YM155 is characterized by its ability to inhibit the export of various proteins from the nucleus to the cytoplasm, which can disrupt cellular processes and be used for research purposes.

YM155 is primarily used in pharmaceutical research as an inhibitor of the nuclear export protein XPO1. It is used to study the effects of perturbing nuclear transport in cells, which can help in understanding and developing treatments for diseases including cancers. Its use is mainly confined to laboratory research and not for clinical applications.

YM155 is safe when handled properly under laboratory conditions. However, it should be used with caution as it may cause skin irritation. Protective measures such as gloves and safety goggles are recommended. The compound is not for oral or dermal use and should be stored away from children and pets. Direct contact with the skin or ingestion should be avoided.

YM155 should be stored in a cool, dry place away from direct sunlight and heat sources. It should be kept at a temperature not exceeding 25°C. The compound should be protected from moisture and should be stored in a tightly sealed container. Proper ventilation should be ensured during handling to prevent inhalation risks. It is advisable to store YM155 in a locked cabinet to prevent unauthorized access.