3,5-Difluoro-2-pyridinecarbaldehyde | CAS No. 780801-58-3
3,5-Difluoro-2-pyridinecarbaldehyde
Basic Information
CAS Number
780801-58-3
Molecular Formula
C6H3F2NO
Molecular Weight
143.09 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- 2-PYRIDINECARBOXALDEHYDE, 3,5-DIFLUORO- (9CI)
- 3,5-difluoro-pyridine-2-carbaldehyde
- 2-Pyridinecarboxaldehyde, 3,5-difluoro-
- A903801
- MFCD11520703
- F11044
- 3,5-difluoropicolinaldehyde
- DTXSID00665431
- LNBLQSIETHAQMW-UHFFFAOYSA-N
- AS-46963
- EN300-322749
- 780801-58-3
- Z1198330229
- CS-0091202
- 3,5-Difluoro-2-pyridinecarboxaldehyde
- AKOS006324947
- 3,5-DIFLUOROPYRIDINE-2-CARBALDEHYDE
- SCHEMBL570418
- 2-Pyridinecarboxaldehyde,3,5-difluoro-
- 3,5-difluoropyridine-2-carbaldehyde
- LogP
MDL Number
MFCD11520703
FAQ
What are the physical and chemical properties of 3,5-Difluoro-2-pyridinecarbaldehyde (CAS: 780801-58-3)?
3,5-Difluoro-2-pyridinecarbaldehyde (CAS: 780801-58-3) is a crystalline solid with a molecular weight of approximately 182.08 g/mol. It has a low solubility in water (less than 0.1 g/L at 25°C) but is more soluble in organic solvents like ethanol and acetone. The compound is moderately reactive, particularly towards nucleophiles and reducing agents. It shows good stability under normal conditions but can undergo rearrangement in the presence of strong bases.
How is 3,5-Difluoro-2-pyridinecarbaldehyde (CAS: 780801-58-3) typically synthesized?
3,5-Difluoro-2-pyridinecarbaldehyde (CAS: 780801-58-3) can be synthesized via the reaction of 2,4,6-trifluoropyridine with phosgene followed by hydrolysis. Alternatively, it can be prepared from 3,5-difluoropyridine through a condensation reaction with acetaldehyde, using a suitable catalyst such as a Lewis acid or other organometallic reagents. The yield and selectivity can be influenced by reaction conditions and the choice of catalyst.
What industries use 3,5-Difluoro-2-pyridinecarbaldehyde (CAS: 780801-58-3)?
3,5-Difluoro-2-pyridinecarbaldehyde (CAS: 780801-58-3) is primarily used in pharmaceuticals for the synthesis of intermediates and active pharmaceutical ingredients. It also finds applications in the polymer industry as a monomer precursor, in the sensor industry for the development of chemical sensors, and in semiconductor materials for doping purposes.
What precautions should be taken when handling 3,5-Difluoro-2-pyridinecarbaldehyde (CAS: 780801-58-3)?
When handling 3,5-Difluoro-2-pyridinecarbaldehyde (CAS: 780801-58-3), it is important to use proper personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials and proper disposal methods. Always refer to the safety data sheet (SDS) for specific handling and disposal instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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