3,5-Difluoro-2-pyridinecarbaldehyde(CAS: 780801-58-3)

3,5-Difluoro-2-pyridinecarbaldehyde (CAS: 780801-58-3) is a crystalline solid with a molecular weight of approximately 182.08 g/mol. It has a low solubility in water (less than 0.1 g/L at 25°C) but is more soluble in organic solvents like ethanol and acetone. The compound is moderately reactive, particularly towards nucleophiles and reducing agents. It shows good stability under normal conditions but can undergo rearrangement in the presence of strong bases.

3,5-Difluoro-2-pyridinecarbaldehyde (CAS: 780801-58-3) can be synthesized via the reaction of 2,4,6-trifluoropyridine with phosgene followed by hydrolysis. Alternatively, it can be prepared from 3,5-difluoropyridine through a condensation reaction with acetaldehyde, using a suitable catalyst such as a Lewis acid or other organometallic reagents. The yield and selectivity can be influenced by reaction conditions and the choice of catalyst.

3,5-Difluoro-2-pyridinecarbaldehyde (CAS: 780801-58-3) is primarily used in pharmaceuticals for the synthesis of intermediates and active pharmaceutical ingredients. It also finds applications in the polymer industry as a monomer precursor, in the sensor industry for the development of chemical sensors, and in semiconductor materials for doping purposes.

When handling 3,5-Difluoro-2-pyridinecarbaldehyde (CAS: 780801-58-3), it is important to use proper personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbent materials and proper disposal methods. Always refer to the safety data sheet (SDS) for specific handling and disposal instructions.