Trioctylphosphine oxide | CAS No. 78-50-2

Q: What are the physical and chemical properties of Trioctylphosphine oxide (CAS: 78-50-2)?

Trioctylphosphine oxide (TOPO, CAS: 78-50-2) is a colorless to slightly yellow oily liquid. It has a molecular weight of approximately 382.51 g/mol and is soluble in organic solvents like methanol, ethanol, and acetone. It is slightly reactive with strong oxidizing agents and basic reagents. Its high solubility and thermal stability make it useful in various chemical applications.

Q: How is Trioctylphosphine oxide (CAS: 78-50-2) typically synthesized?

Trioctylphosphine oxide (TOPO, CAS: 78-50-2) is synthesized by the reaction of trioctylphosphine with hydrogen peroxide in the presence of a base catalyst such as potassium hydroxide. The synthetic process involves careful control of pH and temperature to achieve high yield and selectivity. This method is widely used in the preparation of TOPO for various applications.

Q: What industries use Trioctylphosphine oxide (CAS: 78-50-2)?

Trioctylphosphine oxide (TOPO, CAS: 78-50-2) is extensively used in the pharmaceutical, polymer, and semiconductor industries. It serves as a solvent, a reagent in organic synthesis, and a modifier in the preparation of metal organic frameworks. Additionally, it is utilized in the production of sensors and as a surfactant in certain applications.

Q: What precautions should be taken when handling Trioctylphosphine oxide (CAS: 78-50-2)?

When handling Trioctylphosphine oxide (TOPO, CAS: 78-50-2), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage guidelines.

Trioctylphosphine oxide

Basic Information

View in Editor

CAS Number

78-50-2

Molecular Formula

C24H51OP

Molecular Weight

386.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Insecticides

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

Melting Point

50-52 °C

Boiling Point

201-202 °C/2 mmHg

Density

0,88 g/cm3

Solubility

<1g/l

Refractive Index

1.447

SMILES

View in Editor

CCCCCCCCP(=O)(CCCCCCCC)CCCCCCCC

InChI

InChI=1S/C24H51OP/c1-4-7-10-13-16-19-22-26(25,23-20-17-14-11-8-5-2)24-21-18-15-12-9-6-3/h4-24H2,1-3H3

InChIKey

ZMBHCYHQLYEYDV-UHFFFAOYSA-N

LogP

9.431

Topological Polar Surface Area

17.07 Å²

Hydrogen Bond Donor/Acceptor

0 / 1

Complexity

266

Safety Information

View Safety Information

GHS Hazard Pictograms

H315

H318

Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H318 Causes serious eye damage
Serious eye damage/eye irritation

Stability

Stable. Incompatible with strong oxidizing agents.

Synonyms & References

English

CS-W011744
FT-0688178
tri-n-octylphosphineoxide
AKOS015839960
Cyanex 921
Trioctylphosphine oxide, technical grade, 90%
Tri-n-octylphosphine oxide
Trioctylphosphine oxide, ReagentPlus(R), 99%
T0504
SY009927
Tri-n-octylphosphine oxide; (Trioctylphophine oxide)
A839436
NSC 41937
AS-57931
NSC41937
78-50-2
1-dioctylphosphoryloctane
EXU8U2AM5A
phosphine oxide, trioctyl-;trioctylphosphine oxide;trioctylphosphane oxide;phosphine oxide, trioctyl- trioctylphosphine oxide trioctylphosphane oxide
(OCT)3PO
TOPO
Hostarex PX 324
C24H51OP
LS-106042
MFCD00002083
Phosphine oxide, trioctyl-
EC 201-121-3
Trioctyl phosphine oxide
Trioctylphosphine oxide
DTXSID1052537
SCHEMBL18964

MDL Number

MFCD00002083

Customs Code

32019090

FAQ

What are the physical and chemical properties of Trioctylphosphine oxide (CAS: 78-50-2)?

Trioctylphosphine oxide (TOPO, CAS: 78-50-2) is a colorless to slightly yellow oily liquid. It has a molecular weight of approximately 382.51 g/mol and is soluble in organic solvents like methanol, ethanol, and acetone. It is slightly reactive with strong oxidizing agents and basic reagents. Its high solubility and thermal stability make it useful in various chemical applications.

How is Trioctylphosphine oxide (CAS: 78-50-2) typically synthesized?

Trioctylphosphine oxide (TOPO, CAS: 78-50-2) is synthesized by the reaction of trioctylphosphine with hydrogen peroxide in the presence of a base catalyst such as potassium hydroxide. The synthetic process involves careful control of pH and temperature to achieve high yield and selectivity. This method is widely used in the preparation of TOPO for various applications.

What industries use Trioctylphosphine oxide (CAS: 78-50-2)?

Trioctylphosphine oxide (TOPO, CAS: 78-50-2) is extensively used in the pharmaceutical, polymer, and semiconductor industries. It serves as a solvent, a reagent in organic synthesis, and a modifier in the preparation of metal organic frameworks. Additionally, it is utilized in the production of sensors and as a surfactant in certain applications.

What precautions should be taken when handling Trioctylphosphine oxide (CAS: 78-50-2)?

When handling Trioctylphosphine oxide (TOPO, CAS: 78-50-2), it is important to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up immediately using appropriate absorbents and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and storage guidelines.