N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide

Basic Information

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CAS Number

77377-52-7

Molecular Formula

C9H18F3NOSi

Molecular Weight

241.33 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Specialty Chemicals UV Stabilizers

Basic Physical Properties

Boiling Point

170°C

Density

1.036 g/mL at 25 °C

Refractive Index

n20/D 1.402(lit.)

SMILES

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CC(C)(C)[Si](C)(C)N(C)C(=O)C(F)(F)F

InChI

InChI=1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3

InChIKey

QRKUHYFDBWGLHJ-UHFFFAOYSA-N

LogP

3.0123000000000015

Topological Polar Surface Area

20.310000000000002 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

255

Safety Information

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GHS Hazard Pictograms

H226

H315

H319

H335

Hazard Statement

H226 Flammable liquid and vapor
Flammable liquids

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Hazard Class

Class 3 Class 3

Sensitiveness

Moisture Sensitive

Synonyms & References

English

NS00124766
N-[(tert-Butyl)dimethylsilyl]-N-methyltrifluoroacetamide
n-(t-butyldimethylsilyl)-n-methyltrifluoroacetamide
n-(t-butyldimethylsilyl)-n-methyltrifluoro-acetamide
Acetamide, N-((1,1-dimethylethyl)dimethylsilyl)-2,2,2-trifluoro-N-methyl-
n-(tert-butyldimethylsilyl)-n-methyl-trifluoroacetamide
MFCD00009671
N-(tert-butyldimethylsilyl)-2,2,2-trifluoro-N-methylacetamide
MTBSTFA (with 1% t-BDMCS), (with 1% t-BDMCS), ampule of 5 x 1 mL, analytical standard
N-(Tert-Butyldmethylslyl)-n-methyltrfluoroacetamde
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane
SCHEMBL243947
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane, for GC derivatization, >=95.0% (GC)
N-Methyl-N-(tert-butyldimethylsilyl)-1,1,1-trifluoroacetamide
n-methyl-n-t-butyldimethylsilyltrifluoroacetamide
N-[tert-butyl(dimethyl)silyl]-2,2,2-trifluoro-N-methylacetamide
CN(C(C(F)(F)F)=O)[Si](C)(C)C(C)(C)C
N-Methyl-N-(tert-butyldimethylsilyl)trifluoro-acetamide
J-523187
n-methyl-n-(t-butyldimethylsilyl)trifluoroacetamide
Acetamide, N-[(1,1-dimethylethyl)dimethylsilyl]-2,2,2-trifluoro-N-methyl-
N-(tert-Butyldimethylsilyl)-N-methyltrifluoroacetamide
N-Methyl-(tert-Butydimethylsilyl)-trifluoroacetamide
N-methyl-N-(tert-butyldimethylsilyl)trifluoroacetamide
77377-52-7
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide with 1% tert-Butyldimethylchlorosilane, >=95%
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide
CHEBI:85060
A839071
N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide, >97%
AMY31952

MDL Number

MFCD00009671

FAQ

What regulatory guidelines apply to N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide (CAS: 77377-52-7)?

N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide (CAS: 77377-52-7) falls under the scope of various regulatory guidelines including GHS (Globally Harmonized System of Classification and Labeling of Chemicals) for hazard classification. For EU, it is subject to REACH regulations, which require registration for substances above a certain tonnage. FDA and EPA may have specific requirements related to its use in pharmaceuticals and environmental releases, respectively.

Are there alternatives to N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide (CAS: 77377-52-7) in synthesis?

For syntheses requiring similar functionality, alternatives such as trifluoroacetic anhydride or other trifluoroacetamide derivatives can be considered. These alternatives may offer comparable reactivity but with different reaction profiles and handling requirements.

What is the market or research trend for N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide (CAS: 77377-52-7)?

Market trends for N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide (CAS: 77377-52-7) are driven by its application in organic synthesis, particularly in protecting groups and functional group manipulations. Research is exploring its use in medicinal chemistry and materials science, with a focus on improving synthetic methodologies and environmental compatibility.

How should waste containing N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide (CAS: 77377-52-7) be handled?

Waste containing N-(tert-Butyldimethylsilyl)-N-methyl-trifluoroacetamide (CAS: 77377-52-7) should be collected in appropriate containers and neutralized if necessary. Professional waste disposal services should be used, especially if the waste contains significant amounts. Proper labeling and documentation are essential to comply with environmental protection regulations.