Teneligliptin | CAS No. 760937-92-6

Teneligliptin

Basic Information

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CAS Number

760937-92-6

Molecular Formula

C22H30N6OS

Molecular Weight

426.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Density

1.38

SMILES

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CC1=NN(C(=C1)N2CCN(CC2)C3CC(NC3)C(=O)N4CCSC4)C5=CC=CC=C5

InChI

InChI=1S/C22H30N6OS/c1-17-13-21(28(24-17)18-5-3-2-4-6-18)26-9-7-25(8-10-26)19-14-20(23-15-19)22(29)27-11-12-30-16-27/h2-6,13,19-20,23H,7-12,14-16H2,1H3/t19-,20-/m0/s1

InChIKey

WGRQANOPCQRCME-PMACEKPBSA-N

LogP

1.5661200000000006

Topological Polar Surface Area

56.64000000000001 Å²

Hydrogen Bond Donor/Acceptor

1 / 7

Complexity

594

Synonyms & References

English

MFCD13195565
DTXSID30997419
[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone
TENELIGLIPTIN (CONTAIN AROUND 5% HEXANES)
AKOS025401965
Teliglietin
Q15269678
Teneli
Teneligliptin
((2S,4S)-4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-yl)(thiazolidin-3-yl)methanone
Teneligliptin [INN]
TENELIGLIPTIN [WHO-DD]
NCGC00378896-02
M51
CHEMBL2147777
Teneligliptin (INN)
compound 8g [PMID: 22959556]
AS-83281
GTPL9906
HY-14806
TENELIGLIPTIN [MI]
BDBM50391565
UNII-28ZHI4CF9C
MP-513
D08616
CS-0882
DB11950
AC-27649
{4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-yl}(1,3-thiazolidin-3-yl)methanone
{(2s,4s)-4-[4-(3-Methyl-1-Phenyl-1h-Pyrazol-5-Yl)piperazin-1-Yl]pyrrolidin-2-Yl}(1,3-Thiazolidin-3-Yl)methanone
WGRQANOPCQRCME-PMACEKPBSA-N

MDL Number

MFCD13195565

FAQ

What are the physical and chemical properties of Teneligliptin (CAS: 760937-92-6)?

Teneligliptin is a white to off-white crystalline powder. It has a molecular weight of approximately 348.36 g/mol. Soluble in methanol, ethanol, and water, it shows limited solubility in hexane and chloroform. Chemically, it is stable in neutral and weakly acidic conditions but can be hydrolyzed under basic conditions. Its reactivity is mainly through hydrolysis and oxidation pathways.

How is Teneligliptin (CAS: 760937-92-6) typically synthesized?

Teneligliptin is synthesized via a multi-step process involving the coupling of a protected glycine with a benzamide using a coupling reagent like HATU in the presence of a base such as DIPEA. The key step involves the introduction of the amino group and subsequent protection and deprotection steps. The overall yield is around 50-60%, with high selectivity for the desired product.

What industries use Teneligliptin (CAS: 760937-92-6)?

Teneligliptin is primarily used in the pharmaceutical industry for the treatment of type 2 diabetes. It is not used in polymer, sensor, or semiconductor industries. Its applications are limited to medicinal chemistry and its therapeutic uses.

What precautions should be taken when handling Teneligliptin (CAS: 760937-92-6)?

When handling Teneligliptin, appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn. It should be stored in a cool, dry place away from direct sunlight. In the event of a spill, handle it with care, using absorbent materials, and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.