Teneligliptin(CAS: 760937-92-6)

Teneligliptin is a white to off-white crystalline powder. It has a molecular weight of approximately 348.36 g/mol. Soluble in methanol, ethanol, and water, it shows limited solubility in hexane and chloroform. Chemically, it is stable in neutral and weakly acidic conditions but can be hydrolyzed under basic conditions. Its reactivity is mainly through hydrolysis and oxidation pathways.

Teneligliptin is synthesized via a multi-step process involving the coupling of a protected glycine with a benzamide using a coupling reagent like HATU in the presence of a base such as DIPEA. The key step involves the introduction of the amino group and subsequent protection and deprotection steps. The overall yield is around 50-60%, with high selectivity for the desired product.

Teneligliptin is primarily used in the pharmaceutical industry for the treatment of type 2 diabetes. It is not used in polymer, sensor, or semiconductor industries. Its applications are limited to medicinal chemistry and its therapeutic uses.

When handling Teneligliptin, appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats should be worn. It should be stored in a cool, dry place away from direct sunlight. In the event of a spill, handle it with care, using absorbent materials, and dispose of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and disposal instructions.