(1S,2R)-1-Amino-2-indanol

Basic Information

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CAS Number

7480-35-5

Molecular Formula

C9H11NO

Molecular Weight

149.19 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Physical Properties

Physical State

White to Yellow Solid

SMILES

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C1C(C(C2=CC=CC=C21)N)O

InChI

InChI=1S/C9H11NO/c10-9-7-4-2-1-3-6(7)5-8(9)11/h1-4,8-9,11H,5,10H2/t8-,9+/m1/s1

InChIKey

LOPKSXMQWBYUOI-BDAKNGLRSA-N

LogP

0.6033999999999999

Topological Polar Surface Area

46.25 Å²

Hydrogen Bond Donor/Acceptor

3 / 2

Complexity

149

Safety Information

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GHS Hazard Pictograms

H314

Hazard Statement

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Synonyms & References

English

Z784894996
(1R,2S)-(+)-cis-1-Amino-2-hydroxyindane
cis-1-Amino-2,3-dihydro-1H-inden-2-ol
PS-4272
A885809
EC 422-660-2
(1r, 2s)-cis-1-amino-2-indanol
BP-10106
MFCD00216656
CS-W007401
(1r, 2s)-(+)-cis-1-amino-2-indanol
(1R,2S)-(-)-cis-1-Aminoindan-2-ol;(1R,2S)-1-amino-2,3-dihydro-1H-inden-2-ol;(1R,2S)-(+)-cis-1-Amino-2-indanol
AC-4656
1H-Inden-2-ol, 1-amino-2,3-dihydro-, (1R,2S)-
SCHEMBL163842
cis-(+/-)-1-aminoindan-2-ol
cis-1-Amino-2-indanol, AldrichCPR
(1R, 2S)-1-amino-indan-2-ol
(1R,2S)-amino-2-indanol
(1R,2S)-(+)-1-Amino-2-indanol
1H-Inden-2-ol, 1-amino-2,3-dihydro-, (1R,2S)-rel-
Racemic cis-1-amino-2-indanol
140632-20-8
EN300-53073
P15222
HY-W007401
(1R,2S)-1-amino-2,3-dihydro-1H-inden-2-ol
(1R,2S)-(+)-cis-1-Amino-2-indanol
rel-(1R,2S)-1-Amino-2,3-dihydro-1H-inden-2-ol
LOPKSXMQWBYUOI-DTWKUNHWSA-N
(1R,2S) -(+)-cis-1-amino-2-indanol

MDL Number

MFCD01318239

FAQ

What are the physical and chemical properties of (1S,2R)-1-Amino-2-indanol (CAS: 7480-35-5)?

(1S,2R)-1-Amino-2-indanol (CAS: 7480-35-5) is a crystalline solid with a molecular weight of approximately 146.22 g/mol. It has a solubility of about 0.54 g/100 mL in water and is slightly soluble in ethanol. This compound is reactive, particularly with acidic and basic conditions. It is stable under neutral conditions but requires careful handling due to its sensitivity to moisture and heat.

How is (1S,2R)-1-Amino-2-indanol (CAS: 7480-35-5) typically synthesized?

(1S,2R)-1-Amino-2-indanol (CAS: 7480-35-5) can be synthesized through a multistep process involving the reduction of indanone with sodium borohydride followed by the addition of ammonia. The reaction conditions should be carefully controlled to achieve high selectivity and yield, typically in the presence of a catalytic amount of sodium hydroxide. The final step involves the removal of by-products and purification using recrystallization.

What industries use (1S,2R)-1-Amino-2-indanol (CAS: 7480-35-5)?

(1S,2R)-1-Amino-2-indanol (CAS: 7480-35-5) is primarily used in the pharmaceutical industry as a precursor in the synthesis of various bioactive molecules. It also finds applications in the polymer industry for the development of new materials with specific functional groups. Additionally, it is utilized in the production of sensors and semiconductors due to its unique reactivity and solubility properties.

What precautions should be taken when handling (1S,2R)-1-Amino-2-indanol (CAS: 7480-35-5)?

When handling (1S,2R)-1-Amino-2-indanol (CAS: 7480-35-5), it is essential to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. This compound should be used in a well-ventilated area or a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions and ensure proper storage in a cool, dry area away from direct sunlight and heat sources.