5-Fluoro-1,3-thiazol-2-amine hydrochloride (1:1)

Basic Information

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CAS Number

745053-64-9

Molecular Formula

C3H4ClFN2S

Molecular Weight

154.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Water Treatment Chemicals Disinfectants Chlorine Compounds

Basic Physical Properties

Physical State

White to Yellow Solid

Melting Point

138-143 °C

Boiling Point

221.8°C at 760 mmHg

SMILES

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C1=C(SC(=N1)N)F.Cl

InChI

InChI=1S/C3H3FN2S.ClH/c4-2-1-6-3(5)7-2;/h1H,(H2,5,6);1H

InChIKey

HUXNGTYNEWXYDM-UHFFFAOYSA-N

LogP

1.2861999999999998

Topological Polar Surface Area

38.91 Å²

Hydrogen Bond Donor/Acceptor

2 / 2

Complexity

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2-Amino-5-fluorothiazole hydrochloride, 95%
5-fluorothiazol-2-ylamine hydrochloride
CS-0050490
J-517563
SCHEMBL184746
2-Amino-5-fluorothiazole HCl
AM20100721
SY007487
5-fluoro-1,3-thiazol-2-amine;hydrochloride
5-Fluoro-1,3-thiazol-2-amine hydrochloride (1:1)
5-fluoro-1,3-thiazol-2-amine Hydrochloride
5-fluorothiazol-2-amine HCl
MFCD09056854
DTXSID70474496
5-Fluoro-2-thiazolamine hydrochloride
745053-64-9
5-fluorothiazol-2-amine hydrochloride
FT-0656148
DS-12794
HUXNGTYNEWXYDM-UHFFFAOYSA-N
A9542
Z1198184822
2-amino-5-fluorothiazole hydrochloride
AKOS005258236
C3H4ClFN2S
EN300-175962
5-fluorothiazol-2-amine hydrochloride;2-AMINO-5-FLUOROTHIAZOLE HCL
2-Thiazolamine, 5-fluoro-, monohydrochloride
5-Fluoro-thiazol-2-ylamine hydrochloride
5-Fluorothiazol-2-amine hydrochloride
2-Thiazolamine, 5-fluoro-, hydrochloride

MDL Number

MFCD09056854

Customs Code

2934100090

FAQ

What are the physical and chemical properties of 5-Fluoro-1,3-thiazol-2-amine hydrochloride (CAS: 745053-64-9)?

5-Fluoro-1,3-thiazol-2-amine hydrochloride (CAS: 745053-64-9) is a crystalline compound with a molecular weight of approximately 214.6 g/mol. It has a solubility of about 25 g/L in water and is slightly soluble in ethanol. The compound is stable under normal conditions but reacts with bases to form the corresponding amine. It is typically used in pharmaceuticals and as a reagent in organic synthesis.

How is 5-Fluoro-1,3-thiazol-2-amine hydrochloride (CAS: 745053-64-9) typically synthesized?

5-Fluoro-1,3-thiazol-2-amine hydrochloride (CAS: 745053-64-9) is commonly synthesized via the reaction of thiosemicarbazide with 5-fluoro-1,3-thiazol-2-one in the presence of an acid catalyst. The reaction typically yields high purity product with good selectivity and a high yield of over 90%. The process requires careful control of temperature and reaction time to achieve optimal results.

What industries use 5-Fluoro-1,3-thiazol-2-amine hydrochloride (CAS: 745053-64-9)?

5-Fluoro-1,3-thiazol-2-amine hydrochloride (CAS: 745053-64-9) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also utilized in the sensor industry for its reactivity and in some organic synthesis applications. Its use in the semiconductor industry is limited but it can be explored for specific applications requiring its unique chemical properties.

What precautions should be taken when handling 5-Fluoro-1,3-thiazol-2-amine hydrochloride (CAS: 745053-64-9)?

When handling 5-Fluoro-1,3-thiazol-2-amine hydrochloride (CAS: 745053-64-9), it is important to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. This compound should be used in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be cleaned up using proper laboratory techniques, and the Material Safety Data Sheet (MSDS) should be consulted for detailed safety information and emergency procedures.