4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride

Basic Information

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CAS Number

74197-17-4

Molecular Formula

C7H13Cl2N3

Molecular Weight

210.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1CC2=C(CC1N)C=NN2.Cl.Cl

InChI

InChI=1S/C7H11N3.2ClH/c8-6-1-2-7-5(3-6)4-9-10-7;;/h4,6H,1-3,8H2,(H,9,10);2*1H

InChIKey

IHDUZMHOIVQJGL-UHFFFAOYSA-N

LogP

1.0692999999999995

Topological Polar Surface Area

54.699999999999996 Å²

Hydrogen Bond Donor/Acceptor

3 / 3

Complexity

126

Synonyms & References

English

4,5,6,7-tetrahydro-1H-indazol-5-amine dihydrochloride
IHDUZMHOIVQJGL-UHFFFAOYSA-N
AT27806
4,5,6,7-tetrahydro-1h-indazol-5-amine 2hcl
AS-54382
4,5,6,7-tetrahydro-1H-indazol-5-amine;dihydrochloride
CHEMBL544863
MFCD09028167
5-Amino-4,5,6,7-tetrahydro-1H-indazole dihydrochloride
Z415727968
4,5,6,7-tetrahydro-1H-indazol-5-aminedihydrochloride
SCHEMBL4424183
SY171383
P17826
74197-17-4
EN300-35926
CS-0051115
AKOS025212159
4,5,6,7-Tetrahydro-1H-indazol-5-ylaMine hydrochloride
4,5,6,7-Tetrahydro-1H-indazol-5-amine diHCl
5-amino-4,5,6,7-tetrahydro-2h-indazole dihydrochloride
4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride
4,5,6,7-tetrahydro-2H-indazol-5-ylamine dihydrochloride
SCHEMBL11210316
4,5,6,7-TETRAHYDRO-2H-INDAZOL-5-AMINE 2HCL
4,5,6,7-Tetrahydro-1H-indazol-5-amine hydrochloride
NE55150
5-ami

MDL Number

MFCD18838963

FAQ

What are the physical and chemical properties of 4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride (CAS: 74197-17-4)?

4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride is a crystalline compound with a molecular weight of approximately 246.75 g/mol. It is slightly soluble in water and very soluble in organic solvents like ethanol and acetonitrile. The compound is stable under normal conditions but sensitive to strong bases. It reacts with bases to form the free amine, which can then undergo further reactions such as alkylation or acylation.

How is 4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride (CAS: 74197-17-4) typically synthesized?

4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride can be synthesized by the condensation of indole with an appropriate aldehyde or ketone followed by reduction to form the tetrahydroindazole ring. The dihydrochloride salt is then obtained by protonation. Commonly, this synthesis involves the use of a Lewis acid catalyst like aluminium chloride to promote the condensation step, and sodium borohydride for reduction.

What industries use 4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride (CAS: 74197-17-4)?

4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride is used in various industries, particularly in the pharmaceutical sector for its potential as a drug intermediate. It also finds applications in the synthesis of organic semiconductors and in the development of certain chemical sensors. Its use in polymer chemistry and as an analytical reagent is also noted.

What precautions should be taken when handling 4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride (CAS: 74197-17-4)?

When handling 4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up carefully with appropriate absorbents and disposed of according to local regulations. Always refer to a safety data sheet (SDS) for detailed handling and disposal information.