4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride(CAS: 74197-17-4)

4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride is a crystalline compound with a molecular weight of approximately 246.75 g/mol. It is slightly soluble in water and very soluble in organic solvents like ethanol and acetonitrile. The compound is stable under normal conditions but sensitive to strong bases. It reacts with bases to form the free amine, which can then undergo further reactions such as alkylation or acylation.

4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride can be synthesized by the condensation of indole with an appropriate aldehyde or ketone followed by reduction to form the tetrahydroindazole ring. The dihydrochloride salt is then obtained by protonation. Commonly, this synthesis involves the use of a Lewis acid catalyst like aluminium chloride to promote the condensation step, and sodium borohydride for reduction.

4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride is used in various industries, particularly in the pharmaceutical sector for its potential as a drug intermediate. It also finds applications in the synthesis of organic semiconductors and in the development of certain chemical sensors. Its use in polymer chemistry and as an analytical reagent is also noted.

When handling 4,5,6,7-Tetrahydro-2H-indazol-5-amine dihydrochloride, it is essential to wear appropriate personal protective equipment (PPE) including gloves, safety goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up carefully with appropriate absorbents and disposed of according to local regulations. Always refer to a safety data sheet (SDS) for detailed handling and disposal information.