(11beta)-21-Acetoxy-11-hydroxy-3,20-dioxopregn-4-en-17-yl propionate | CAS No. 74050-20-7
(11beta)-21-Acetoxy-11-hydroxy-3,20-dioxopregn-4-en-17-yl propionate
Basic Information
CAS Number
74050-20-7
Molecular Formula
C26H36O7
Molecular Weight
460.57 g/mol
AD
Chemical Classification
Basic Physical Properties
Melting Point
144-146°C
Density
1.23±0.1 g/cm3 (20 ºC 760 Torr),
Solubility
Insuluble (9.7E-3 g/L) (25 ºC),
Synonyms & References
English
- Efficort
- HYDROCORTISONE ACEPONATE [WHO-DD]
- Q15409432
- MS-28453
- Hydrocortisoni aceponas [Latin]
- Hydrocortisone 17-propionate 21-acetate 100 microg/mL in Acetonitrile
- HYDROCORTISONE ACEPONATE COMPONENT OF EASOTIC
- CHEMBL2106309
- CHEBI:135746
- NCGC00532512-01
- Suniderma
- HYDROCORTISONE ACEPONATE (EMA EPAR: VETERINARY)
- Aceponato de hidrocortisona
- Cortavance
- DB14538
- Aceponate d'hydrocortisone
- Hydrocortisoni aceponas
- SCHEMBL3697
- 21-(acetyloxy)-11beta-hydroxy-17alpha-(propionyloxy)-4-pregnene-3,20-dione
- Hydrocortisone aceponate [INN]
- Pregn-4-ene-3,20-dione, 21-(acetyloxy)-11-hydroxy-17-(1-oxopropoxy)-, (11?)-; (11?)-21-(Acetyloxy)-11-hydroxy-17-(1-oxopropoxy)pregn-4-ene-3,20-dione; Cortisol 17-propionate 21-acetate; Hydrocortisone 17-propionate 21-acetate; Hydrocortisone aceponate; Retef
- EASOTIC COMPONENT HYDROCORTISONE ACEPONATE
- HY-116691
- F82273
- [(8S,9S,10R,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-11-hydroxy-10,13-dimethyl-3-oxo-2,6,7,8,9,11,12,14,15,16-decahydro-1H-cyclopenta[a]phenanthren-17-yl] propanoate
- Hydrocortisoni aceponas (Latin)
- Hydrocortisone aceponate;Hydrocortisone
- Hydrocortisoneaceponate
- (8S,9S,10R,11S,13S,14S,17R)-17-(2-Acetoxyacetyl)-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl propionate
- Hydrocortisone aceponate (INN)
- Aceponate d'hydrocortisone [French]
MDL Number
MFCD00866010
FAQ
What are the physical and chemical properties of (11beta)-21-Acetoxy-11-hydroxy-3,20-dioxopregn-4-en-17-yl propionate (CAS: 74050-20-7)?
This compound is a crystalline solid with a molecular weight of approximately 412.44 g/mol. It has a low solubility in water but is more soluble in organic solvents like ethanol and acetone. It is moderately reactive, particularly in acidic conditions. The compound exhibits a characteristic melting point around 150-155°C and is stable under normal conditions.
How is (11beta)-21-Acetoxy-11-hydroxy-3,20-dioxopregn-4-en-17-yl propionate (CAS: 74050-20-7) typically synthesized?
This compound is typically synthesized through a series of reactions involving the acetylation of progesterone followed by esterification with propionic acid. The synthesis involves precise control over temperature and pH, with the use of a catalytic amount of a strong acid like sulfuric acid to facilitate the acetylation step. The product is purified using column chromatography and recrystallization techniques.
What industries use (11beta)-21-Acetoxy-11-hydroxy-3,20-dioxopregn-4-en-17-yl propionate (CAS: 74050-20-7)?
This compound is primarily used in the pharmaceutical industry, where it serves as an intermediate in the synthesis of progestins and other steroid hormones. It has applications in research and development, particularly in the formulation of contraceptives and hormone replacement therapies.
What precautions should be taken when handling (11beta)-21-Acetoxy-11-hydroxy-3,20-dioxopregn-4-en-17-yl propionate (CAS: 74050-20-7)?
When handling this compound, it is crucial to wear appropriate personal protective equipment (PPE), including gloves, safety goggles, and lab coats. It should be stored in a well-ventilated area, away from heat and sources of ignition. In case of a spill, use appropriate spill response materials, and consult the Safety Data Sheet (SDS) for detailed instructions.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
You might also like
Compound Q&A
What is 6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one (CAS: 21889-89-4)?
6-Methyl-7-oxabicyclo[4.1.0]heptan-2-one is a cyclic ketone with a molecular for...
21889-89-46-Methyl-7-oxabicycl...
Compound Q&A
What is 4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid (CAS: 906353-00-2)?
4-[(6-Methyl-2-pyrazinyl)oxy]benzoic acid is a chemical compound with the CAS nu...
906353-00-24-[(6-Methyl-2-pyraz...
Compound Q&A
What is 2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8)?
2-(2-Pyridinyl)-1,3-propanediol (CAS: 49745-42-8) is a colorless to slightly yel...
49745-42-82-(2-Pyridinyl)-1,3-...
Compound Q&A
What is 2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile (CAS: 24783-42-4)?
2-(6-Chloro-2-pyridinyl)-2-phenylacetonitrile is an organic compound with the CA...
24783-42-42-(6-Chloro-2-pyridi...
Compound Q&A
What is 2-Oxopropanamide (CAS: 631-66-3)?
2-Oxopropanamide, also known as 2-aminoacrylic acid, is a chemical compound with...
631-66-32-Oxopropanamide
Compound Q&A
What is 2-Methyl-2-propanyl 4-(5-bromo-6-methyl-2-pyridinyl)-1-piperazinecarboxylate (CAS: 1289040-88-5)?
2-Methyl-2-propanyl 4-(5-bromo-6-methyl-2-pyridinyl)-1-piperazinecarboxylate (CA...
1289040-88-52-Methyl-2-propanyl ...
Compound Q&A
What is NAMPT inhibitor-linker 1 (CAS: 2241019-57-6)?
NAMPT inhibitor-linker 1 (CAS: 2241019-57-6) is a chemical compound designed as ...
2241019-57-6NAMPT inhibitor-link...
Compound Q&A
What is (2-(2,2,2-Trifluoroacetyl)pyridin-4-yl)boronic acid (CAS: 1310404-58-0)?
It is a chemical compound with the structure (2-(2,2,2-Trifluoroacetyl)pyridin-4...
1310404-58-0(2-(2,2,2-Trifluoroa...
Compound Q&A
What is 1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (CAS: 794568-90-4)?
1-(2-Chlorophenyl)-6-(3,3,3-trifluoro-2-methylpropyl)-1,5-dihydro-4H-pyrazolo[3,...
794568-90-41-(2-Chlorophenyl)-6...
Compound Q&A
What is Vinyl(chloromethyl)dimethoxysilane (CAS: 1314981-48-0)?
Vinyl(chloromethyl)dimethoxysilane is an organosilicon compound with the molecul...
1314981-48-0Vinyl(chloromethyl)d...
